Literature DB >> 3187197

Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced depletion of brain acetylcholine levels in gerbils.

N Ogawa1, K Haba, H Yoshikawa, T Ono, K Mizukawa.   

Abstract

Effects of bifemelane hydrochloride, idebenone and indeloxazin hydrochloride on ischemia-induced decrease in acetylcholine (ACh) levels were studied in gerbils. Among these three drugs, only bifemelane hydrochloride significantly inhibited the decrease in ACh concentration in the cerebral cortex, hippocampus and striatum of ischemic gerbils. This suggests that bifemelane hydrochloride has an anti-ischemic action and beneficial effects on various symptoms induced by ischemia.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3187197

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  6 in total

1.  Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line.

Authors:  I Miyazaki; E Iwata-Ichikawa; M Asanuma; M Iida; N Ogawa
Journal:  Neurochem Res       Date:  1999-07       Impact factor: 3.996

2.  Acetylcholinesterase inhibitor ENA-713 protects against ischemia-induced decrease in pre- and postsynaptic cholinergic indices in the gerbil brain following transient ischemia.

Authors:  K Tanaka; N Ogawa; K Mizukawa; M Asanuma; Y Kondo; S Nishibayashi; A Mori
Journal:  Neurochem Res       Date:  1994-02       Impact factor: 3.996

3.  Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced changes in brain monoamines and their metabolites in gerbils.

Authors:  K Haba; N Ogawa; M Asanuma; H Hirata; A Mori
Journal:  J Neural Transm Gen Sect       Date:  1992

4.  Effects of chronic bifemelane hydrochloride administration on receptors for N-methyl-D-aspartate in the aged-rat brain.

Authors:  N Ogawa; K Mizukawa; K Haba; M Asanuma; A Mori
Journal:  Neurochem Res       Date:  1992-07       Impact factor: 3.996

Review 5.  Idebenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders.

Authors:  J C Gillis; P Benefield; D McTavish
Journal:  Drugs Aging       Date:  1994-08       Impact factor: 3.923

6.  The effects of sho-saiko-to-go-keishi-ka-shakuyaku-to (TJ-960) on ischemia-induced changes of brain acetylcholine and monoamine levels in gerbils.

Authors:  K Haba; N Ogawa; A Mori
Journal:  Neurochem Res       Date:  1990-05       Impact factor: 3.996
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.