| Literature DB >> 31870703 |
Jung Nyeo Chun1, Minsoo Cho2, Soonbum Park3, Insuk So1, Ju-Hong Jeon4.
Abstract
The transcription factor E2F1 plays a crucial role in mediating multiple cancer hallmark capabilities that regulate cell cycle, survival, apoptosis, metabolism, and metastasis. Aberrant activation of E2F1 is closely associated with a poor clinical outcome in various human cancers. However, E2F1 has conflictingly been reported to exert tumor suppressive activity, raising a question as to the nature of its substantive role in the control of cell fate. In this review, we summarize deregulated E2F1 activity and its role in prostate cancer. We highlight the recent advances in understanding the molecular mechanism by which E2F1 regulates the development and progression of prostate cancer, providing insight into how cell context or data interpretation shapes the role of E2F1 in prostate cancer. This review will aid in translating biomedical knowledge into therapeutic strategies for prostate cancer.Entities:
Keywords: E2F1; Oncogenic role; Prostate cancer; Tumor suppressive role
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Year: 2019 PMID： 31870703 DOI： 10.1016/j.bbcan.2019.188336
Source DB: PubMed Journal: Biochim Biophys Acta Rev Cancer ISSN： 0304-419X Impact factor: 10.680