Shahin Safian 1 , Farzaneh Esna-Ashari 2 , Shiva Borzouei 3 Show Affiliations »
Abstract
AIMS: Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus. BACKGROUND: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM). METHODS: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24-28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22. RESULTS: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008). CONCLUSION: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
AIMS: Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus . BACKGROUND: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO ) antibodies in pregnant women with gestational diabetes mellitus (GDM ). METHODS: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24-28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22. RESULTS: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008). CONCLUSION: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Chemical
Disease
Gene
Species
Keywords:
Thyroid diseases; diabetes; gestational; glucose tolerance test; pregnant women; thyroid peroxidase
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Year: 2020
PMID： 31870270 DOI： 10.2174/1573399816666191223111833
Source DB: PubMed Journal: Curr Diabetes Rev ISSN： 1573-3998