Tale of Two Magnets: An Advanced Magnetic Targeting System.

Magnetic targeting strategies employ external magnet fields to manipulate magnetic nanoparticles (MNPs) remotely, aiming to enhance their accumulation and penetration in vivo, which have received increasing attention in drug-delivery systems over the past decades. However, this approach has not yet been successful in translational clinical studies, largely due to the low efficacy and uncontrollable distribution of MNPs. The standard magnetic targeting strategy uses a single magnet and, thus, suffers from rapid drop-off of the magnetic field and field gradient with increasing distance away from the magnet surface. As a result, magnetic targeting of MNPs is often limited to superficial regions of interest. As reported in this issue of ACS Nano, Andrew Tsourkas and his colleagues showed that a two-magnet configuration can solve this dilemma by introducing a constant field gradient between the magnets for advanced magnetic targeting. The custom-built two-magnet device evidenced greatly enhanced accumulation and penetration of MNPs in a solid tumor model, shedding new light on future design considerations of magnetic targeting systems.