Serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes.

Dear Editor,

The report on “Positive correlation of serum leptin levels and peripheral arterial stiffness (PAS) in patients with type 2 diabetes (DM)” is very interesting [1]. Lu et al. concluded that “The serum leptin level could be a predictor of PAS in type 2 DM patients [1].” In fact, the clinical relationship between serum leptin in DM is well described in the literature. Nevertheless, there are also other factors that might alter the serum leptin level, and this might be a limitation in using serum leptin as a clinical parameter in metabolic syndrome [2]. The underlying liver dysfunction is a good example [2] and this might be the big consideration in the setting with high prevalence of liver disease such as East and Southeast Asian counties.

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