Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Sodium butyrate increases glucose transporter expression in LLC-PK1 cells.

Literature DB >> 3186708

Sodium butyrate increases glucose transporter expression in LLC-PK1 cells.

Abstract

The effect of sodium butyrate on the expression of the facilitated glucose transporter (GT) was investigated in the pig kidney cell line LLC-PK1. When cells were treated with butyrate, GT mRNA expression was remarkably enhanced with a maximal effect at 5 mM. Levels of GT mRNA were increased at 1 day after butyrate treatment and continued to increase for at least 4 days; however, acetate and propionate did not affect GT mRNA levels significantly. The induction of GT mRNA by butyrate was accompanied by an increase in GT function. The expression of GT mRNA decreased in HepG2, HT-29, and COS cells by treatment with butyrate for 1 day. Interestingly, glucose deprivation of LLC-PK1 cells reduced the induction of GT mRNA by butyrate, although starvation itself slightly enhanced steady-state GT mRNA levels. Therefore, expression of GT in LLC-PK1 cells is strongly induced by butyrate by a pathway that apparently depends on the presence of glucose in culture medium.

Entities: Chemical Species

Mesh：

Substances：

Year: 1988 PMID： 3186708 PMCID： PMC282356 DOI： 10.1073/pnas.85.21.8072

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

38 in total

Review 1. Glucose transport in the kidney.

Authors: M Silverman
Journal: Biochim Biophys Acta Date: 1976-12-14

2. Apparent translocation of glucose transport activity in rat epididymal adipocytes by insulin-like effects of high pH or hyperosmolarity.

Authors: N Toyoda; F W Robinson; M M Smith; J E Flanagan; T Kono
Journal: J Biol Chem Date: 1986-02-15 Impact factor: 5.157

3. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein.

Authors: M J Birnbaum; H C Haspel; O M Rosen
Journal: Proc Natl Acad Sci U S A Date: 1986-08 Impact factor: 11.205

Review 4. Hormonal regulation of mammalian glucose transport.

Authors: I A Simpson; S W Cushman
Journal: Annu Rev Biochem Date: 1986 Impact factor: 23.643

5. Sequence and structure of a human glucose transporter.

Authors: M Mueckler; C Caruso; S A Baldwin; M Panico; I Blench; H R Morris; W J Allard; G E Lienhard; H F Lodish
Journal: Science Date: 1985-09-06 Impact factor: 47.728

6. Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.

Authors: J S Flier; M Mueckler; A L McCall; H F Lodish
Journal: J Clin Invest Date: 1987-02 Impact factor: 14.808

7. Regulation of hexose transporters in chicken embryo fibroblasts: stimulation by the phorbol ester TPA leads to increased numbers of functioning transporters.

Authors: K Yamada; L G Tillotson; K J Isselbacher
Journal: J Cell Physiol Date: 1986-05 Impact factor: 6.384

2. Salivary and Gut Microbiomes Play a Significant Role in in Vitro Oral Bioaccessibility, Biotransformation, and Intestinal Absorption of Arsenic from Food.

Authors: Marta Calatayud; Chan Xiong; Gijs Du Laing; Georg Raber; Kevin Francesconi; Tom van de Wiele
Journal: Environ Sci Technol Date: 2018-12-04 Impact factor: 9.028

2 in total

Sodium butyrate increases glucose transporter expression in LLC-PK1 cells.

Review 1. Glucose transport in the kidney.

2. Apparent translocation of glucose transport activity in rat epididymal adipocytes by insulin-like effects of high pH or hyperosmolarity.

3. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein.

Review 4. Hormonal regulation of mammalian glucose transport.

5. Sequence and structure of a human glucose transporter.

6. Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man.

7. Regulation of hexose transporters in chicken embryo fibroblasts: stimulation by the phorbol ester TPA leads to increased numbers of functioning transporters.

8. Expression of type C-related endogenous retroviral sequences in human colon tumors and colon cancer cell lines.

9. Regulation of the rat metallothionein-I gene by sodium butyrate.

10. Glucose deprivation and hexose transporter polypeptides of murine fibroblasts.

1. Regulation of glucose transporters in LLC-PK1 cells: effects of D-glucose and monosaccharides.

2. Salivary and Gut Microbiomes Play a Significant Role in in Vitro Oral Bioaccessibility, Biotransformation, and Intestinal Absorption of Arsenic from Food.