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Literature DB >> 31867073

Perspectives in TSPO PET Imaging for Neurologic Diseases.

Abstract

The translocator protein (18 kDa) (TSPO) is a mitochondrial transmembrane protein, which has brought attention as a neuroinflammatory biomarker. Positron emission tomography (PET) imaging studies have been done for several decades, since neuroinflammation has been implicated as an important pathophysiology of several common neurologic disorders. However, despite numerous previous studies with positive findings, its clinical significance is not yet clear. Various attempts to overcome the limitations are ongoing, in order to bring acceptance for use in clinics. © Korean Society of Nuclear Medicine 2019.

Entities: Disease Gene

Keywords: Neuroinflammation; Neurologic disease; Positron emission tomography; Translocator protein (18 kDa)

Year: 2019 PMID： 31867073 PMCID： PMC6898699 DOI： 10.1007/s13139-019-00620-y

Source DB: PubMed Journal: Nucl Med Mol Imaging ISSN： 1869-3474

34 in total

1. Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study.

Authors: Paul Edison; Hilary A Archer; Alexander Gerhard; Rainer Hinz; Nicola Pavese; Federico E Turkheimer; Alexander Hammers; Yen Fong Tai; Nick Fox; Angus Kennedy; Martin Rossor; David J Brooks
Journal: Neurobiol Dis Date: 2008-08-15 Impact factor: 5.996

2. Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: a PET study with the TSPO molecular imaging biomarker [((11))C]vinpocetine.

Authors: Balázs Gulyás; Miklós Tóth; Martin Schain; Anu Airaksinen; Adám Vas; Konstantinos Kostulas; Per Lindström; Jan Hillert; Christer Halldin
Journal: J Neurol Sci Date: 2012-07-27 Impact factor: 3.181

3. Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG.

Authors: Stephen F Carter; Michael Schöll; Ove Almkvist; Anders Wall; Henry Engler; Bengt Långström; Agneta Nordberg
Journal: J Nucl Med Date: 2012-01 Impact factor: 10.057

Review 4. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.

Authors: Vassilios Papadopoulos; Mario Baraldi; Tomás R Guilarte; Thomas B Knudsen; Jean-Jacques Lacapère; Peter Lindemann; Michael D Norenberg; David Nutt; Abraham Weizman; Ming-Rong Zhang; Moshe Gavish
Journal: Trends Pharmacol Sci Date: 2006-07-05 Impact factor: 14.819

5. Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study.

Authors: Alie Schuitemaker; Marc A Kropholler; Ronald Boellaard; Wiesje M van der Flier; Reina W Kloet; Thalia F van der Doef; Dirk L Knol; Albert D Windhorst; Gert Luurtsema; Frederik Barkhof; Cees Jonker; Adriaan A Lammertsma; Philip Scheltens; Bart N M van Berckel
Journal: Neurobiol Aging Date: 2012-07-26 Impact factor: 4.673

6. Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding.

Authors: Samuel Murail; Jean-Claude Robert; Yves-Marie Coïc; Jean-Michel Neumann; Mariano A Ostuni; Zhin-Xing Yao; Vassilios Papadopoulos; Nadège Jamin; Jean-Jacques Lacapère
Journal: Biochim Biophys Acta Date: 2008-03-27

7. Kinetic modeling without accounting for the vascular component impairs the quantification of [(11)C]PBR28 brain PET data.

Authors: Gaia Rizzo; Mattia Veronese; Matteo Tonietto; Paolo Zanotti-Fregonara; Federico E Turkheimer; Alessandra Bertoldo
Journal: J Cereb Blood Flow Metab Date: 2014-03-26 Impact factor: 6.200

8. Imaging Striatal Microglial Activation in Patients with Parkinson's Disease.

Authors: Yuko Koshimori; Ji-Hyun Ko; Romina Mizrahi; Pablo Rusjan; Rostom Mabrouk; Mark F Jacobs; Leigh Christopher; Clement Hamani; Anthony E Lang; Alan A Wilson; Sylvain Houle; Antonio P Strafella
Journal: PLoS One Date: 2015-09-18 Impact factor: 3.240

9. Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO).

Authors: Alessandro Colasanti; David R Owen; Detelina Grozeva; Eugenii A Rabiner; Paul M Matthews; Nick Craddock; Allan H Young
Journal: Psychoneuroendocrinology Date: 2013-08-12 Impact factor: 4.905

Review 10. The methodology of TSPO imaging with positron emission tomography.

Authors: Federico E Turkheimer; Gaia Rizzo; Peter S Bloomfield; Oliver Howes; Paolo Zanotti-Fregonara; Alessandra Bertoldo; Mattia Veronese
Journal: Biochem Soc Trans Date: 2015-08-03 Impact factor: 5.407

2 in total

1. Neuroinflammation in cognitive decline post-cardiac surgery (the FOCUS study): an observational study protocol.

Authors: Annemieke M Peters van Ton; Harmke B Duindam; Julia van Tuijl; Wilson Wl Li; Hendrik-Jan Dieker; Niels P Riksen; Fj Anton Meijer; Roy Pc Kessels; Nils Kohn; Johannes G van der Hoeven; Peter Pickkers; Mark Rijpkema; Wilson F Abdo
Journal: BMJ Open Date: 2021-05-11 Impact factor: 2.692

2. TSPO Expression Modulatory Effect of Acetylcholinesterase Inhibitor in the Ischemic Stroke Rat Model.

Authors: Yoo Sung Song; Sang Hee Lee; Jae Ho Jung; In Ho Song; Hyun Soo Park; Byung Seok Moon; Sang Eun Kim; Byung Chul Lee
Journal: Cells Date: 2021-05-29 Impact factor: 6.600

2 in total