Literature DB >> 31866207

The role of ceramides in skin homeostasis and inflammatory skin diseases.

Qingyang Li1, Hui Fang1, Erle Dang1, Gang Wang2.   

Abstract

Ceramides, members of sphingolipid family, are not only the building blocks of epidermal barrier structure, but also bioactive metabolites involved in epidermal self-renewal and immune regulation. Hence, abnormal ceramide expression profile is recognized to defect extracellular lipid organization, disturb epidermal self-renewal, exacerbate skin immune response and actively participate in progression of several inflammatory dermatoses, exemplifying by psoriasis and atopic dermatitis. Here, we discuss recent advances in understanding skin ceramides and their regulatory roles in skin homeostasis and pathogenic roles of altered ceramide metabolism in inflammatory skin diseases. These insights provide new opportunities for therapeutic intervention in inflammatory dermatoses.
Copyright © 2019 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Atopic dermatitis; Ceramides; Epidermal barrier; Inflammatory dermatoses; Psoriasis

Year:  2019        PMID： 31866207     DOI： 10.1016/j.jdermsci.2019.12.002

Source DB:  PubMed          Journal:  J Dermatol Sci        ISSN： 0923-1811            Impact factor:   4.563


  10 in total

1.  Effect of Chimpi, dried citrus peel, on aquaporin-3 expression in HaCaT human epidermal keratinocytes.

Authors:  Nobutomo Ikarashi; Miho Kaneko; Daigo Wakana; Yui Shinozaki; Keito Tabata; Yui Nishinaka; Ryotaro Yoshida; Tomofumi Watanabe; Nobuyuki Wakui; Risako Kon; Hiroyasu Sakai; Junzo Kamei; Tomoo Hosoe
Journal:  Mol Biol Rep       Date:  2022-08-28       Impact factor: 2.742

2.  Effect of Rice (Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study.

Authors:  Teik Kee Leo; Eugenie Sin Sing Tan; Farahnaz Amini; Navedur Rehman; Edmond Siah Chye Ng; Chung Keat Tan
Journal:  Nutrients       Date:  2022-06-30       Impact factor: 6.706

3.  Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis.

Authors:  Petra Pavel; Géraldine Leman; Martin Hermann; Christian Ploner; Thomas O Eichmann; Deborah Minzaghi; Franz P W Radner; Barbara Del Frari; Robert Gruber; Sandrine Dubrac
Journal:  JID Innov       Date:  2021-06-15

4.  Accelerated Barrier Repair in Human Skin Explants Induced with a Plant-Derived PPAR-α Activating Complex via Cooperative Interactions.

Authors:  George Majewski; John Craw; Timothy Falla
Journal:  Clin Cosmet Investig Dermatol       Date:  2021-09-18

Review 5.  The Role of Sphingolipids in Allergic Disorders.

Authors:  Araceli Díaz-Perales; Maria M Escribese; María Garrido-Arandia; David Obeso; Elena Izquierdo-Alvarez; Jaime Tome-Amat; Domingo Barber
Journal:  Front Allergy       Date:  2021-06-14

6.  A Skin Lipidomics Study Reveals the Therapeutic Effects of Tanshinones in a Rat Model of Acne.

Authors:  Tingting Chen; Zhaoming Zhu; Qunqun Du; Zhuxian Wang; Wenfeng Wu; Yaqi Xue; Yuan Wang; Yufan Wu; Quanfu Zeng; Cuiping Jiang; Chunyan Shen; Li Liu; Hongxia Zhu; Qiang Liu
Journal:  Front Pharmacol       Date:  2021-06-10       Impact factor: 5.810

7.  Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide.

Authors:  Kazuhiro Kagotani; Hiroko Nakayama; Liqing Zang; Yuki Fujimoto; Akihito Hayashi; Ryoji Sono; Norihiro Nishimura; Yasuhito Shimada
Journal:  Molecules       Date:  2020-03-31       Impact factor: 4.411

8.  Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu.

Authors:  Ruzica Jurakic Toncic; Ivone Jakasa; Suzana Ljubojevic Hadzavdic; Susan Mi Goorden; Karen Jm Ghauharali-van der Vlugt; Femke S Stet; Anamaria Balic; Mikela Petkovic; Borna Pavicic; Kristina Zuzul; Branka Marinovic; Sanja Kezic
Journal:  Int J Mol Sci       Date:  2020-03-13       Impact factor: 5.923

9.  Wheat Extract Oil (WEO) Attenuates UVB-Induced Photoaging via Collagen Synthesis in Human Keratinocytes and Hairless Mice.

Authors:  Dong Ju Son; Jae Chul Jung; Yong Min Choi; Hyeon Yeol Ryu; Somin Lee; Barbara A Davis
Journal:  Nutrients       Date:  2020-01-22       Impact factor: 5.717

Review 10.  The Role of the Microbiome and Microbiome-Derived Metabolites in Atopic Dermatitis and Non-Histaminergic Itch.

Authors:  Wei Li; Gil Yosipovitch
Journal:  Am J Clin Dermatol       Date:  2020-09       Impact factor: 7.403
  10 in total

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