Rui Huang1, Xiuxia Li2, Shihong Xu3, Dingpeng Li3, Peijing Yan4, Bo Liu5, Xingwen Xie6, Kehu Yang7. 1. Gansu University of Chinese Medicine, Lanzhou 730000, China; Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China. 2. Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China. 3. Gansu Institute of Traditional Chinese Medicine, Lanzhou 730050, China; Department of Bone Oncology, Gansu Provincial Hospital of Tradition Chinese Medicine, Lanzhou 730050, China. 4. Institute of Clinical Research and Evidence Based Medicine, Gansu Provincial People's Hospital, Lanzhou 730000, China. 5. Gansu University of Chinese Medicine, Lanzhou 730000, China. 6. Gansu Institute of Traditional Chinese Medicine, Lanzhou 730050, China; Department of Bone Oncology, Gansu Provincial Hospital of Tradition Chinese Medicine, Lanzhou 730050, China. kehuyangebm2006@163.com. 7. Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China; Institute of Clinical Research and Evidence Based Medicine, Gansu Provincial People's Hospital, Lanzhou 730000, China; 7Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
Abstract
BACKGROUND: Acupoint injection has currently received increasing attention as a treatment for primary osteoporosis (POP), This study aimed to evaluate the efficacy and safety of acupoint injection as a clinical treatment for POP. METHODS: Randomized controlled trials (RCTs) of acupoint injection compared with conventional non-acupoint injection for POP were identified in searches of seven databases from their inception to March 2019. All data were assessed and extracted by two authors independently. The risk of bias assessment recommended by the Cochrane Collaboration was used to assess the quality of the selected studies. RevMan 5.3 was used to conduct meta-analysis for the efficacy and safety of acupoint injection. RESULTS: Five trials with 337 patients (aged 45-86 years) with bone mineral density (BMD) ≤2 SD were included in our meta-analysis. The results showed that, compared with conventional intramuscular injection, acupoint injection significantly increased the BMD [mean difference (MD) =0.02; 95% CI, 0.01 to 0.03, P<0.00001]. Subgroup analysis indicated that acupoint injection significantly improved lumbar BMD (MD =0.02; 95% CI, 0.01 to 0.03, P<0.00001) but did not reduce the pain score (SMD =-2.29, 95% CI, -6.81 to 2.23, P>0.05). Individuals results showed that acupoint injection improved biochemical indicators, such as NBAP, IGF-I and reduced CTX and leptin levels. While the risk of bias was high in all five trials. CONCLUSIONS: This meta-analysis and systematic review suggests that acupoint injection improves BMD and some biochemical indicators in POP patients compared with the effects of conventional intramuscular injection. However, due to the high risk of bias in all the trials reviewed, the evidence remains inconclusive and future research will be required with improved methodological quality.
BACKGROUND: Acupoint injection has currently received increasing attention as a treatment for primary osteoporosis (POP), This study aimed to evaluate the efficacy and safety of acupoint injection as a clinical treatment for POP. METHODS: Randomized controlled trials (RCTs) of acupoint injection compared with conventional non-acupoint injection for POP were identified in searches of seven databases from their inception to March 2019. All data were assessed and extracted by two authors independently. The risk of bias assessment recommended by the Cochrane Collaboration was used to assess the quality of the selected studies. RevMan 5.3 was used to conduct meta-analysis for the efficacy and safety of acupoint injection. RESULTS: Five trials with 337 patients (aged 45-86 years) with bone mineral density (BMD) ≤2 SD were included in our meta-analysis. The results showed that, compared with conventional intramuscular injection, acupoint injection significantly increased the BMD [mean difference (MD) =0.02; 95% CI, 0.01 to 0.03, P<0.00001]. Subgroup analysis indicated that acupoint injection significantly improved lumbar BMD (MD =0.02; 95% CI, 0.01 to 0.03, P<0.00001) but did not reduce the pain score (SMD =-2.29, 95% CI, -6.81 to 2.23, P>0.05). Individuals results showed that acupoint injection improved biochemical indicators, such as NBAP, IGF-I and reduced CTX and leptin levels. While the risk of bias was high in all five trials. CONCLUSIONS: This meta-analysis and systematic review suggests that acupoint injection improves BMD and some biochemical indicators in POPpatients compared with the effects of conventional intramuscular injection. However, due to the high risk of bias in all the trials reviewed, the evidence remains inconclusive and future research will be required with improved methodological quality.
Authors: Minghui Liu; Yinyu Wang; Ning Li; Jin Cui; WenRui Fan; Shuo Yang; Li Li; Jie Zeng; Min Li Journal: Medicine (Baltimore) Date: 2021-12-23 Impact factor: 1.817