Recent progress in the knowledge on the alleviating effect of nitric oxide on heavy metal stress in plants.

Recently, nitric oxide (NO), a redox-related signaling molecule, is considered to be a key regulator in plant growth and development as well as response to abiotic stresses. Heavy metal (HM) stress is one of the most serious threats to affect crop growth and production. HM stress attributes to the production of reactive oxygen species (ROS), leading to oxidative stress in plants. Thus, to minimize the toxic effects of HM stress, plants directly or indirectly activate different ROS-scavenging mechanisms comprised antioxidative enzymes and non-enzymatic antioxidants. Understanding the roles of NO is essential to elucidate how NO activates the appropriate set of responses to HM stress. Moreover, the regulation of key genes or proteins is very important in response to stress stimuli. Therefore, here we focus on the recent knowledge concerning the alleviating effect of NO on HM stress, covering from HM iron accumulation to antioxidant system to related gene and protein expression.