Literature DB >> 31865041

Type 3 IP3 receptors driving oncogenesis.

Flore Sneyers1, Nicolas Rosa1, Geert Bultynck2.   

Abstract

Type 3 Inositol 1,4,5-trisphosphate (IP3) receptors (IP3R3s) have been identified as anti-oncogenic channels by propelling pro-apoptotic Ca2+ signals to mitochondria. Yet, recent studies (Rezuchova et al, Cell Death Dis, 2019; Ueasilamongkol et al, Hepathology, 2019; Guerra et al, Gut, 2019) revealed that IP3R3 upregulation drives oncogenesis via ER-mitochondrial Ca2+ crosstalk, adding complexity to IP3R3's role in cancer.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Calcium signaling; Cancer; IP3R3 channels; ITPR3; Oncogenesis

Mesh：

Substances：

Year:  2019        PMID： 31865041     DOI： 10.1016/j.ceca.2019.102141

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  5 in total

1.  Identification of ITPR1 as a Hub Gene of Group 3 Medulloblastoma and Coregulated Genes with Potential Prognostic Values.

Authors:  Pablo Ferreira das Chagas; Graziella Ribeiro de Sousa; Luciana Chain Veronez; Andrea Martins-da-Silva; Carolina Alves Pereira Corrêa; Gustavo Alencastro Veiga Cruzeiro; Luis Fernando Peinado Nagano; Rosane Gomes de Paula Queiroz; Suely Kazue Nagahashi Marie; Silvia Regina Brandalise; Carlos Alberto Scrideli; Luiz Gonzaga Tone; Elvis Terci Valera
Journal:  J Mol Neurosci       Date:  2021-11-25       Impact factor: 3.444

Review 2.  Crosstalks between inflammasome and autophagy in cancer.

Authors:  Chaeuk Chung; Wonhyoung Seo; Prashanta Silwal; Eun-Kyeong Jo
Journal:  J Hematol Oncol       Date:  2020-07-23       Impact factor: 17.388

3.  Dominant mutations in ITPR3 cause Charcot-Marie-Tooth disease.

Authors:  Julius Rönkkö; Svetlana Molchanova; Anya Revah-Politi; Elaine M Pereira; Mari Auranen; Jussi Toppila; Jouni Kvist; Anastasia Ludwig; Julika Neumann; Geert Bultynck; Stéphanie Humblet-Baron; Adrian Liston; Anders Paetau; Claudio Rivera; Matthew B Harms; Henna Tyynismaa; Emil Ylikallio
Journal:  Ann Clin Transl Neurol       Date:  2020-09-19       Impact factor: 4.511

4.  ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.

Authors:  Mengzhao Zhang; Lu Wang; Yangyang Yue; Lu Zhang; Tianjie Liu; Minxuan Jing; Xiao Liang; Minghai Ma; Shan Xu; Ke Wang; Xinyang Wang; Jinhai Fan
Journal:  J Exp Clin Cancer Res       Date:  2021-02-11

Review 5.  Inositol 1,4,5-Trisphosphate Receptors in Human Disease: A Comprehensive Update.

Authors:  Jessica Gambardella; Angela Lombardi; Marco Bruno Morelli; John Ferrara; Gaetano Santulli
Journal:  J Clin Med       Date:  2020-04-12       Impact factor: 4.241
  5 in total

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