Literature DB >> 31864211

New insights into phenotypic switching of VSMCs induced by hyperhomocysteinemia: Role of endothelin-1 signaling.

Yulong Chen1, Xingli Su2, Qiaohong Qin3, Yue Yu3, Min Jia4, Hongmei Zhang5, Huijin Li3, Leilei Pei6.   

Abstract

Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis. HHcy induces phenotypic switching of VSMCs, but the mechanism is unclear. Endothelin-1 (ET-1) promotes proliferation and migration of VSMCs by inducing phenotypic switching during atherosclerosis. This review examined recent findings on the relationship between HHcy or the ET-1 system (including ET-1 and its receptors) and phenotypic switching of VSMCs as well as the molecular mechanism of HHcy-regulated ET-1 signaling. In particular, we focused on the potential mechanisms and pharmacological targets of phenotypic switching of VSMCs regulated by HHcy through ET-1 signaling.
Copyright © 2019 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

Entities:  

Keywords:  Endothelin-1 signaling; Hyperhomocysteinemia; Phenotypic switching; Vascular smooth muscle cells

Mesh：

Substances：

Year:  2019        PMID： 31864211     DOI： 10.1016/j.biopha.2019.109758

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  8 in total

Review 1.  Role of mitochondrial dynamics and mitophagy of vascular smooth muscle cell proliferation and migration in progression of atherosclerosis.

Authors:  Diem Thi Ngoc Huynh; Kyung-Sun Heo
Journal:  Arch Pharm Res       Date:  2021-11-07       Impact factor: 4.946

2.  Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.

Authors:  Ying-Ying Wu; Yi-Lin Huang; Bin Dai; Jian-Wei Liu; Xu Han
Journal:  Evid Based Complement Alternat Med       Date:  2022-05-31       Impact factor: 2.650

3.  Deletion of Ulk1 inhibits neointima formation by enhancing KAT2A/GCN5-mediated acetylation of TUBA/α-tubulin in vivo.

Authors:  Changhan Ouyang; Jian Li; Xiaoxu Zheng; Jing Mu; Gloria Torres; Qilong Wang; Ming-Hui Zou; Zhonglin Xie
Journal:  Autophagy       Date:  2021-05-14       Impact factor: 13.391

4.  Ginsenoside Rh1 Inhibits Angiotensin II-Induced Vascular Smooth Muscle Cell Migration and Proliferation through Suppression of the ROS-Mediated ERK1/2/p90RSK/KLF4 Signaling Pathway.

Authors:  Diem Thi Ngoc Huynh; Yujin Jin; Dung Van Nguyen; Chang-Seon Myung; Kyung-Sun Heo
Journal:  Antioxidants (Basel)       Date:  2022-03-27

Review 5.  Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells.

Authors:  Adnan Badran; Suzanne A Nasser; Joelle Mesmar; Ahmed F El-Yazbi; Alessandra Bitto; Manal M Fardoun; Elias Baydoun; Ali H Eid
Journal:  Int J Mol Sci       Date:  2020-11-20       Impact factor: 5.923

6.  Glossogyne tenuifolia Attenuates Proliferation and Migration of Vascular Smooth Muscle Cells.

Authors:  Chin-Feng Hsuan; Yung-Chuan Lu; I-Ting Tsai; Jer-Yiing Houng; Shih-Wei Wang; Tzu-Hsien Chang; Ya-Ling Chen; Chi-Chang Chang
Journal:  Molecules       Date:  2020-12-10       Impact factor: 4.411

Review 7.  O-Linked β-N-Acetylglucosamine Modification: Linking Hypertension and the Immune System.

Authors:  Rinaldo Rodrigues Dos Passos Junior; Gisele Facholi Bomfim; Fernanda R Giachini; Rita C Tostes; Victor Vitorino Lima
Journal:  Front Immunol       Date:  2022-03-17       Impact factor: 7.561

Review 8.  Inflammation in Coronary Atherosclerosis and Its Therapeutic Implications.

Authors:  Nicholas J Montarello; Mau T Nguyen; Dennis T L Wong; Stephen J Nicholls; Peter J Psaltis
Journal:  Cardiovasc Drugs Ther       Date:  2020-11-10       Impact factor: 3.727
  8 in total

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