| Literature DB >> 31864140 |
Hidenori Ogata1, Noriko Isobe2, Xu Zhang3, Ryo Yamasaki4, Takayuki Fujii5, Akira Machida6, Nobutoshi Morimoto7, Kenichi Kaida8, Teruaki Masuda9, Yukio Ando10, Motoi Kuwahara11, Susumu Kusunoki12, Yuri Nakamura13, Takuya Matsushita14, Jun-Ichi Kira15.
Abstract
To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with those of healthy Japanese controls. All IgG4 anti-NF155 antibody-positive CIDP patients exclusively carried either HLA-DRB1*15:01-DRB5*01:01-DQA1*01:02-DQB1*06:02 or -(A*24:02)-B*52:01-C*12:02-DRB1*15:02-DRB5*01:02-DQA1*01:03-DQB1*06:01, resulting in significantly increased HLA-DRB1*15, -DRB1*15:01, -DQB1*06:01/06:02, -DQB1*06:02, and -DRB1*15:01-DQB1*06:02 frequencies compared with healthy Japanese controls. These findings indicate the involvement of specific HLA class II molecules in the pathomechanisms of IgG4 anti-NF155 antibody-positive CIDP.Entities:
Keywords: Chronic inflammatory demyelinating polyneuropathy; HLA; Haplotype; IgG4; Neurofascin 155
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Year: 2019 PMID： 31864140 DOI： 10.1016/j.jneuroim.2019.577139
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478