Yuliya Tipograf1, Whitney D Gannon2, Neal M Foley3, Ahmed Hozain4, Rei Ukita5, Matthew Warhoover6, William McMaster7, Jonathan C Nesbitt5, Ashish S Shah3, Matthew Bacchetta8. 1. Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Surgery, Columbia University Medical Center, New York, New York. 2. Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. 3. Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee. 4. Department of Biomedical Engineering, Columbia University Medical Center, New York, New York. 5. Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee. 6. Department of Perfusion, Vanderbilt University Medical Center, Nashville, Tennessee. 7. Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee. 8. Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Biomedical Engineering, Columbia University Medical Center, New York, New York. Electronic address: matthew.bacchetta@vumc.org.
Abstract
BACKGROUND: Single-site, dual-lumen venovenous extracorporeal membrane oxygenation ECMO) facilitates mobilization, reduces recirculation, and mitigates insertion and infectious risks of an additional access site. This study reports the experience with a bicaval dual-lumen cannula that comprises a robust physical design allowing for easy and safe cannulation, precise positioning and monitoring, and appropriate physiologic support for patients with acute respiratory failure. METHODS: Statistical analysis was performed from data gathered retrospectively from the electronic medical records of 20 adult patients who were cannulated for ECMO with this bicaval dual-lumen cannula from August 2018 through May 2019. RESULTS: Gas exchange and blood flow were optimized in all patients after cannulation (median pH, 7.42 [interquartile range {IQR}, 7.39, 7.44], ratio of arterial partial pressure of oxygen to fraction of inspired oxygen, 186.5 [Pao2:Fio2, 116.5, 247.0]; pump flow, 3.9 L/min [IQR, 3.1, 4.3]). Eleven patients (55%) were able to be freed from mechanical ventilation after cannulation, 9 (45%) patients underwent a tracheostomy procedure while undergoing ECMO, and no patients required reintubation. No morbidity or mortality was related to the cannulation strategy or the catheter. Two patients required cannula repositioning. Survival to decannulation was 90%, and survival to hospital discharge was 80%. CONCLUSIONS: The bicaval dual-lumen cannula maintains the advantages of upper body single-site configuration to provide the adjunctive respiratory support necessary to facilitate awakening and rehabilitation while minimizing the use of invasive mechanical ventilation. This cannula introduces design qualities that may offer advantages for acute respiratory failure requiring venovenous ECMO.
BACKGROUND: Single-site, dual-lumen venovenous extracorporeal membrane oxygenation ECMO) facilitates mobilization, reduces recirculation, and mitigates insertion and infectious risks of an additional access site. This study reports the experience with a bicaval dual-lumen cannula that comprises a robust physical design allowing for easy and safe cannulation, precise positioning and monitoring, and appropriate physiologic support for patients with acute respiratory failure. METHODS: Statistical analysis was performed from data gathered retrospectively from the electronic medical records of 20 adult patients who were cannulated for ECMO with this bicaval dual-lumen cannula from August 2018 through May 2019. RESULTS: Gas exchange and blood flow were optimized in all patients after cannulation (median pH, 7.42 [interquartile range {IQR}, 7.39, 7.44], ratio of arterial partial pressure of oxygen to fraction of inspired oxygen, 186.5 [Pao2:Fio2, 116.5, 247.0]; pump flow, 3.9 L/min [IQR, 3.1, 4.3]). Eleven patients (55%) were able to be freed from mechanical ventilation after cannulation, 9 (45%) patients underwent a tracheostomy procedure while undergoing ECMO, and no patients required reintubation. No morbidity or mortality was related to the cannulation strategy or the catheter. Two patients required cannula repositioning. Survival to decannulation was 90%, and survival to hospital discharge was 80%. CONCLUSIONS: The bicaval dual-lumen cannula maintains the advantages of upper body single-site configuration to provide the adjunctive respiratory support necessary to facilitate awakening and rehabilitation while minimizing the use of invasive mechanical ventilation. This cannula introduces design qualities that may offer advantages for acute respiratory failure requiring venovenous ECMO.
Authors: Patrick T Hussey; Gregory von Mering; Navin C Nanda; Mustafa I Ahmed; Dylan R Addis Journal: Echocardiography Date: 2022-01-07 Impact factor: 1.874
Authors: Anil J Trindade; Whitney D Gannon; John W Stokes; Eric S Lambright; Katie A McPherson; Stephanie G Norfolk; Ivan M Robbins; Ciara M Shaver; Matthew Bacchetta Journal: Transplant Direct Date: 2022-09-16