Georgia Karpathiou1, Celine Chauleur2, Mousa Mobarki3, Michel Peoc'h4. 1. Department of Pathology, North Hospital, University Hospital of St-Etienne, France. Electronic address: gakarpath@yahoo.gr. 2. Department of Obstetrics and Gynecology, North Hospital, University Hospital of St-Etienne, France. 3. Department of Pathology, North Hospital, University Hospital of St-Etienne, France; Department of Pathology, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia. 4. Department of Pathology, North Hospital, University Hospital of St-Etienne, France.
Abstract
BACKGROUND: Evasion of immune control is a major feature of malignant tumors. This tumor aspect is poorly studied in cervical lesions. AIM OF THE STUDY: To investigate the expression of PD-L1 and CTLA-4 in lesions of the uterine cervix. MATERIAL AND METHODS: Sixty-three cervical lesions from 52 patients were immunohistochemically studied. The 63 lesions included 27 invasive adenocarcinomas, 19 squamous cell carcinomas (SCCs), 7 adenocarcinomas in situ, and 10 high-grade squamous intraepithelial lesions (CIN3). RESULTS: CTLA-4 and PD-L1 tumor cell expression was found in 61.5 % and 26.9 % of the invasive cases, respectively. CTLA-4 tumor cell expression and PD-L1 tumor and immune cell expression were more often found in SCCs than in adenocarcinomas. CTLA-4 tumor cell expression was more often found in advanced FIGO tumors. PD-L1 and CTLA-4 immune cell expression was associated with lymph node metastasis. CTLA-4 expression did not affect survival. The prognosis was worse for PD-L1-expressing tumors. CONCLUSION: CTLA-4 and PD-L1 are potential therapeutic targets in cervical cancer.
BACKGROUND: Evasion of immune control is a major feature of malignant tumors. This tumor aspect is poorly studied in cervical lesions. AIM OF THE STUDY: To investigate the expression of PD-L1 and CTLA-4 in lesions of the uterine cervix. MATERIAL AND METHODS: Sixty-three cervical lesions from 52 patients were immunohistochemically studied. The 63 lesions included 27 invasive adenocarcinomas, 19 squamous cell carcinomas (SCCs), 7 adenocarcinomas in situ, and 10 high-grade squamous intraepithelial lesions (CIN3). RESULTS:CTLA-4 and PD-L1 tumor cell expression was found in 61.5 % and 26.9 % of the invasive cases, respectively. CTLA-4tumor cell expression and PD-L1 tumor and immune cell expression were more often found in SCCs than in adenocarcinomas. CTLA-4tumor cell expression was more often found in advanced FIGO tumors. PD-L1 and CTLA-4 immune cell expression was associated with lymph node metastasis. CTLA-4 expression did not affect survival. The prognosis was worse for PD-L1-expressing tumors. CONCLUSION:CTLA-4 and PD-L1 are potential therapeutic targets in cervical cancer.
Authors: Mickey V Patel; Zheng Shen; Marta Rodriguez-Garcia; Edward J Usherwood; Laura J Tafe; Charles R Wira Journal: Front Immunol Date: 2021-04-23 Impact factor: 7.561