Unraveling the Footsteps of Proteomics in Male Reproductive Research: A Scientometric Approach.

Significance: Male reproductive research at molecular level has gained more attention as it offers the cellular mechanisms and biological pathways implicated in the reproductive physiology. Several researchers across the world have used global proteomic approach in conjunction with advanced bioinformatics software to identify putative biomarkers for various male infertility conditions. Recent Advances: Introduction of advance proteomic platforms has made it easier to generate enormous amount of data in a short period of time. In this article, we have reviewed the functional and comparative proteomic studies in the area of male reproductive research. We have discussed the key proteins and associated cellular pathways such as oxidative phosphorylation and mitochondrial dysfunction implicated in the various male infertility conditions. Furthermore, for the first time scientometric approach was used to analyze the publication trends and hot topics in proteomics of male reproductive research. Critical Issues: Analysis of publication trends revealed that majority of the published studies were focused on varicocele and asthenozoospermia, while very limited research has been conducted on assisted reproductive technology (ART). This area of research requires more attention as it would facilitate identification of novel biomarkers to catalogue proteomic characteristics of spermatozoa for achieving better results in ART. Future Directions: Future research should be focused on the development and validation of a biomarker panel for specific male infertility scenarios based on etiology. Translation of validated proteomic biomarkers into tests or assays for male infertility conditions would enable the physician to provide better management for the patients.