Pablo Melonari1, Héctor Abate1, Luis Hernán Llano López1, Rubén J Cutlca2, M Teresa Apaz3, Cristina Battagliotti4, Iris Vilca5, Aldo Cancellara2, Miriam Calvari3, Alejandro Ellis6, Adrián G Collia6, Luis Pedro Flynn7, Alicia Aletti8, Gustavo Lazarte8, Juan Petricca9, Ivana P Tonetto10, Alejandro Santillán11, Mariana Brusadín12, Alejandra Gaiano13. 1. Hospital Pediátrico Dr. Humberto Notti. Guaymallén, Provincia de Mendoza, República Argentina. 2. Hospital de Niños Pedro de Elizalde, Provincia de Buenos Aires, República Argentina. 3. Hospital Pediátrico del Niño Jesús, Provincia de Córdoba, República Argentina. 4. Hospital de Niños Dr. Orlando Alassia, Provincia de Santa Fe, República Argentina. 5. Hospital Materno Infantil Héctor Quintana, Provincia de Jujuy, República Argentina. 6. Sanatorio Mater Dei, Provincia de Buenos Aires, República Argentina. 7. Sanatorio de Niños de Rosario, Provincia de Santa Fe, República Argentina. 8. Hospital de Niños Víctor J. Vilela, Provincia de Santa Fe, República Argentina. 9. Hospital Schestakov, Provincia de Mendoza, República Argentina. 10. Hospital Interzonal de Agudos "José Penna", Provincia de Buenos Aires, República Argentina. 11. Hospital Interzonal de Niños Eva Perón, Provincia de Catamarca, República Argentina. 12. Hospital Español, Provincia de Mendoza, República Argentina. 13. Hospital Materno Infantil de San Isidro, Provincia de Buenos Aires, República Argentina.
Abstract
BACKGROUND: Kawasaki disease (EK) is an acute systemic vasculitis with a risk of developing coronary aneurysms. AIM: To describe the clinical and epidemiological characteristics of children with EK in Argentina and to analyse the risk factors for the development of coronary's complications (CC). METHODS: Multicenter, retrospective, cross-sectional, observational and analytical study. It included patients younger than 18 years of age diagnosed with EK in hospitals in Argentina, between January the 1st, 2010 and December the 31th, 2013. RESULTS: N = 193 subjects. Age: medium: 29 months. Total incidence 5 cases / 10,000 hospital discharges. CC was observed in 15.5% of patients. Increased risk factors for CC: Elevated number of days with fever at the time of treatment placement (p = 0.0033); Increased of: heart frequency (p = 0.0021), erythrosedimentation (ESR) (p = 0.005), C-reactive protein (CRP) (p < 0.0001), leukocytes (p = 0.0006), neutrophils (p = 0.0021); Decreased of hematocrit (p = 0.0007) and hemoglobin (p < 0.0001).Association with CC: non-coronary cardiological alterations (OR = 10,818); PCR greater than 68 mg /L (OR = 11,596); leukocytes greater than 20,000 / mm3 (OR = 4.316); and ESR greater than 64 mm / 1 hour (OR = 4.267). CONCLUSION: The most frequent form of presentation was complete EK, the risk of CC was higher in males, younger than 5 years old, the risk factors (clinical and laboratory) were similar to those described in the literature.
BACKGROUND:Kawasaki disease (EK) is an acute systemic vasculitis with a risk of developing coronary aneurysms. AIM: To describe the clinical and epidemiological characteristics of children with EK in Argentina and to analyse the risk factors for the development of coronary's complications (CC). METHODS: Multicenter, retrospective, cross-sectional, observational and analytical study. It included patients younger than 18 years of age diagnosed with EK in hospitals in Argentina, between January the 1st, 2010 and December the 31th, 2013. RESULTS: N = 193 subjects. Age: medium: 29 months. Total incidence 5 cases / 10,000 hospital discharges. CC was observed in 15.5% of patients. Increased risk factors for CC: Elevated number of days with fever at the time of treatment placement (p = 0.0033); Increased of: heart frequency (p = 0.0021), erythrosedimentation (ESR) (p = 0.005), C-reactive protein (CRP) (p < 0.0001), leukocytes (p = 0.0006), neutrophils (p = 0.0021); Decreased of hematocrit (p = 0.0007) and hemoglobin (p < 0.0001).Association with CC: non-coronary cardiological alterations (OR = 10,818); PCR greater than 68 mg /L (OR = 11,596); leukocytes greater than 20,000 / mm3 (OR = 4.316); and ESR greater than 64 mm / 1 hour (OR = 4.267). CONCLUSION: The most frequent form of presentation was complete EK, the risk of CC was higher in males, younger than 5 years old, the risk factors (clinical and laboratory) were similar to those described in the literature.