| Literature DB >> 31859471 |
Tengling Wu1, Chunyan Cui1, Yuting Huang2, Yang Liu1, Chuanchuan Fan1, Xiaoxu Han1, Yang Yang1, Ziyang Xu1, Bo Liu1, Guanwei Fan2, Wenguang Liu1.
Abstract
Over the past decade, tissue-engineering strategies, mainly involving injectable hydrogels and epicardial biomaterial patches, have been pursued to treat myocardial infarction. However, only limited therapeutic efficacy is achieved with a single means. Here, a combined therapy approach is proposed, that is, the coadministration of a conductive hydrogel patch and injectable hydrogel to the infarcted myocardium. The self-adhesive conductive hydrogel patch is fabricated based on Fe3+-induced ionic coordination between dopamine-gelatin (GelDA) conjugates and dopamine-functionalized polypyrrole (DA-PPy), which form a homogeneous network. The injectable and cleavable hydrogel is formed in situ via a Schiff base reaction between oxidized sodium hyaluronic acid (HA-CHO) and hydrazided hyaluronic acid (HHA). Compared with a single-mode system, injecting the HA-CHO/HHA hydrogel intramyocardially followed by painting a conductive GelDA/DA-PPy hydrogel patch on the heart surface results in a more pronounced improvement of the cardiac function in terms of echocardiographical, histological, and angiogenic outcomes.Entities:
Keywords: cardiac function; coadministration; conductive hydrogel patch; injectable hydrogel; myocardial infarction
Mesh：
Substances：
Year: 2020 PMID： 31859471 DOI： 10.1021/acsami.9b17907
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229