Han-Wen Chang1, Ekaterina V Nizovtseva1, Sergey V Razin2,3, Tim Formosa4, Katerina V Gurova5, Vasily M Studitsky1,3. 1. Cancer Epigenetics Program, Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19422, USA. 2. Institute of Gene Biology RAS, 34/5 Vavilov Str., 119334 Moscow, Russia. 3. Biology Faculty, Lomonosov Moscow State University, 1 Leninskie Gory, 119992 Moscow, Russia. 4. Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA. 5. Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY14263, USA.
Abstract
The histone chaperone FACT plays important roles in essentially every chromatin-associated process and is an important indirect target of the curaxin class of anti-cancer drugs. Curaxins are aromatiс compounds that intercalate into DNA and can trap FACT in bulk chromatin, thus interfering with its distribution and its functions in cancer cells. Recent studies have provided mechanistic insight into how FACT and curaxins cooperate to promote unfolding of nucleosomes and chromatin fibers, resulting in genome-wide disruption of contact chromatin domain boundaries, perturbation of higher order chromatin organization, and global disregulation of gene expression. Here, we discuss the implications of these insights for cancer biology.
The histone chaperone FACT plays important roles in essentially every chromatin-associated process and is an important indirect target of the curaxin class of anti-cancer drugs. Curaxins are aromatiс compounds that intercalate into DNA and can trap FACT in bulk chromatin, thus interfering with its distribution and its functions inn class="Disease">cancer cells. Recent studies have provided mechanistic insight into how FACT and curaxins cooperate to promote unfolding of nucleosomes and chromatin fibers, resulting in genome-wide disruption of contact chromatin domain boundaries, perturbation of higher order chromatin organization, and global disregulation of gene expression. Here, we discuss the implications of these insights for cancer biology.
Authors: Jason D True; Joseph J Muldoon; Melissa N Carver; Kunal Poorey; Savera J Shetty; Stefan Bekiranov; David T Auble Journal: J Biol Chem Date: 2016-05-16 Impact factor: 5.157
Authors: Julien Matysiak; Paul Lesbats; Eric Mauro; Delphine Lapaillerie; Jean-William Dupuy; Angelica P Lopez; Mohamed Salah Benleulmi; Christina Calmels; Marie-Line Andreola; Marc Ruff; Manuel Llano; Olivier Delelis; Marc Lavigne; Vincent Parissi Journal: Retrovirology Date: 2017-07-28 Impact factor: 4.602
Authors: Omar L Kantidze; Artem V Luzhin; Ekaterina V Nizovtseva; Alfiya Safina; Maria E Valieva; Arkadiy K Golov; Artem K Velichko; Alexander V Lyubitelev; Alexey V Feofanov; Katerina V Gurova; Vasily M Studitsky; Sergey V Razin Journal: Nat Commun Date: 2019-03-29 Impact factor: 14.919
Authors: Ting Zhang; Chaoran Yin; Aleksandr Fedorov; Liangjun Qiao; Hongliang Bao; Nazar Beknazarov; Shiyu Wang; Avishekh Gautam; Riley M Williams; Jeremy Chase Crawford; Suraj Peri; Vasily Studitsky; Amer A Beg; Paul G Thomas; Carl Walkley; Yan Xu; Maria Poptsova; Alan Herbert; Siddharth Balachandran Journal: Nature Date: 2022-05-25 Impact factor: 69.504