Literature DB >> 31852198

Effects of voluntary running exercise on skeletal muscle properties in nonobese rats with type 2 diabetes.

I Nakamoto1, A Ishihara.   

Abstract

The skeletal muscles of animals and humans with type 2 diabetes have decreased oxidative capacity. Aerobic exercise can improve muscle oxidative capacity, but no data are available on the amount of exercise required. We investigated the effects of voluntary running exercise and running distance on the skeletal muscle properties of nonobese rats with type 2 diabetes. Six-week-old male diabetic Goto-Kakizaki rats were divided into nonexercised (GK) and exercised (GK-Ex) groups. The rats in the GK-Ex group were permitted voluntary running exercise on wheels for 6 weeks. Age-matched male Wistar rats (WR) were used as nondiabetic controls. Fasting blood glucose and HbA1c levels were higher in the GK and GK-Ex groups than in the WR group and lower in the GK-Ex group than in the GK group. Succinate dehydrogenase (SDH) activity and peroxisome proliferator-activated receptor gamma coactivator-1alpha (Pgc-1alpha) mRNA levels in the soleus and plantaris muscles were higher in the WR and GK-Ex groups than in the GK group. HbA1c and total cholesterol levels were negatively correlated with running distance and SDH activity and Pgc-1alpha mRNA levels in the soleus muscle were positively correlated with running distance. The onset and progression of diabetes in nonobese diabetic rats were effectively inhibited by running longer distances.

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Year:  2019        PMID： 31852198      PMCID： PMC8565956          DOI： 10.33549/physiolres.934178

Source DB:  PubMed          Journal:  Physiol Res        ISSN： 0862-8408            Impact factor:   1.881


  37 in total

1.  High-fat diet-induced reduction of peroxisome proliferator-activated receptor-γ coactivator-1α messenger RNA levels and oxidative capacity in the soleus muscle of rats with metabolic syndrome.

Authors:  Fumiko Nagatomo; Hidemi Fujino; Hiroyo Kondo; Isao Takeda; Kinsuke Tsuda; Akihiko Ishihara
Journal:  Nutr Res       Date:  2012-02       Impact factor: 3.315

2.  GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: is insulin resistance in type 2 diabetes a slow, type 1 fiber disease?

Authors:  M Gaster; P Staehr; H Beck-Nielsen; H D Schrøder; A Handberg
Journal:  Diabetes       Date:  2001-06       Impact factor: 9.461

3.  Exercise training impacts exercise tolerance and bioenergetics in gastrocnemius muscle of non-obese type-2 diabetic Goto-Kakizaki rat in vivo.

Authors:  Michael Macia; Emilie Pecchi; Martine Desrois; Carole Lan; Christophe Vilmen; Bernard Portha; Monique Bernard; David Bendahan; Benoît Giannesini
Journal:  Biochimie       Date:  2018-02-28       Impact factor: 4.079

4.  The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome.

Authors:  Fumiko Nagatomo; Hidemi Fujino; Hiroyo Kondo; Motoki Kouzaki; Ning Gu; Isao Takeda; Kinsuke Tsuda; Akihiko Ishihara
Journal:  J Physiol Sci       Date:  2012-01-11       Impact factor: 2.781

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Journal:  Cell       Date:  1999-07-09       Impact factor: 41.582

6.  Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP.

Authors:  Shinji Miura; Eriko Tomitsuka; Yasutomi Kamei; Tomomi Yamazaki; Yuko Kai; Mayumi Tamura; Kiyoshi Kita; Ichizo Nishino; Osamu Ezaki
Journal:  Am J Pathol       Date:  2006-10       Impact factor: 4.307

7.  Fibre type distribution and gene expression levels of both succinate dehydrogenase and peroxisome proliferator-activated receptor-gamma coactivator-1alpha of fibres in the soleus muscle of Zucker diabetic fatty rats.

Authors:  Tetsuya Adachi; Naoko Kikuchi; Koichiro Yasuda; Reiko Anahara; Ning Gu; Tetsuro Matsunaga; Tsubasa Yamamura; Chisato Mori; Gozoh Tsujimoto; Kinsuke Tsuda; Akihiko Ishihara
Journal:  Exp Physiol       Date:  2006-12-07       Impact factor: 2.969

8.  Effects of hyperbaric exposure with high oxygen concentration on glucose and insulin levels and skeletal muscle-fiber properties in diabetic rats.

Authors:  Koichiro Yasuda; Tetsuya Adachi; Ning Gu; Akiko Matsumoto; Tetsuro Matsunaga; Gozoh Tsujimoto; Kinsuke Tsuda; Akihiko Ishihara
Journal:  Muscle Nerve       Date:  2007-03       Impact factor: 3.217

9.  Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles.

Authors:  Shinji Miura; Yuko Kai; Misaki Ono; Osamu Ezaki
Journal:  J Biol Chem       Date:  2003-05-30       Impact factor: 5.157

10.  Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.

Authors:  Jiandie Lin; Hai Wu; Paul T Tarr; Chen-Yu Zhang; Zhidan Wu; Olivier Boss; Laura F Michael; Pere Puigserver; Eiji Isotani; Eric N Olson; Bradford B Lowell; Rhonda Bassel-Duby; Bruce M Spiegelman
Journal:  Nature       Date:  2002-08-15       Impact factor: 49.962
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  3 in total

Review 1.  Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats.

Authors:  B S M Galán; T D A Serdan; L E Rodrigues; R Manoel; R Gorjão; L N Masi; T C Pithon-Curi; R Curi; S M Hirabara
Journal:  Braz J Med Biol Res       Date:  2022-05-27       Impact factor: 2.904

Review 2.  Pathophysiology of exercise-induced muscle damage and its structural, functional, metabolic, and clinical consequences.

Authors:  A Stožer; P Vodopivc; L Križančić Bombek
Journal:  Physiol Res       Date:  2020-07-16       Impact factor: 1.881

3.  Preventive effects of low-intensity endurance exercise for severe hyperglycemia-induced capillary regression in non-obese type 2 diabetes rat skeletal muscle.

Authors:  Takeshi Morifuji; Minoru Tanaka; Ryosuke Nakanishi; Takumi Hirabayashi; Hiroyo Kondo; Hidemi Fujino
Journal:  Physiol Rep       Date:  2021-01
  3 in total

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