A variable embryotoxic response to lead in different strains of hamsters.

Lead nitrate was administered intravenously at 50 mg/kg to five inbred strains (MHA, LSH, LHC, CB, and P)4) and the non-inbred LVG strain of pregnant hamsters early on the 8th gestation day. All fetuses from treated and control hamsters were collected on the 15th gestation day and examined for the frequency and kinds of external, internal, and skeletal abnormalities. The major embryotoxic effects included resorptions, tail bud abnormalities, hydrocephalus, and skeletal defects. It is concluded that the LSH, LHC, LVG, and PD4 strains are susceptible while the MHA and CB strains are relatively resistant to the lead exposure.