Literature DB >> 3185116

Phospholipid analysis of human eosinophils: high levels of alkylacylglycerophosphocholine (PAF precursor).

A Ojima-Uchiyama1, Y Masuzawa, T Sugiura, K Waku, H Saito, Y Yui, H Tomioka.   

Abstract

The phospholipid composition and fatty acid profiles of human eosinophils were studied. Extremely high levels of ether phospholipids were found in this type of cell, such as alkylacylglycerophosphocholine (GPC) and alkenylacylglycerophosphoethanolamine (GPE); these two ether phospholipids accounted for about three-fourths of the choline and ethanolamine glycerophospholipids (CGP and EGP), respectively. Fatty acid analyses revealed that very large portions of arachidonic acid (20:4) were esterified to alkylacyl-GPC (92.0% in CGP) and alkenylacyl-GPE (86.6% in EGP), respectively. While high amounts of alkylacyl-GPC and the abundance of 20:4 in this ether phospholipid have been observed in other types of blood cells of various animals, these percentages for human eosinophils are the highest among such cells. These results suggest that alkyl and alkenyl ether phospholipids play essential roles in human eosinophils in various physiological and pathological conditions.

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Year:  1988        PMID： 3185116     DOI： 10.1007/bf02536227

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  24 in total

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Authors:  G Rouser; A N Siakotos; S Fleischer
Journal:  Lipids       Date:  1966-01       Impact factor: 1.880

2.  Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan.

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Journal:  FEBS Lett       Date:  1985-09-23       Impact factor: 4.124

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Journal:  J Clin Invest       Date:  1986-12       Impact factor: 14.808

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Authors:  B R Horn; E D Robin; J Theodore; A Van Kessel
Journal:  N Engl J Med       Date:  1975-05-29       Impact factor: 91.245

5.  Monocytes activate eosinophils for enhanced helminthotoxicity and increased generation of leukotriene C4.

Authors:  P Elsas; T H Lee; H L Lenzi; A J Dessein
Journal:  Ann Inst Pasteur Immunol       Date:  1987 Jan-Feb

6.  Increased biosynthesis of platelet-activating factor in activated human eosinophils.

Authors:  T Lee; D J Lenihan; B Malone; L L Roddy; S I Wasserman
Journal:  J Biol Chem       Date:  1984-05-10       Impact factor: 5.157

7.  Release of arachidonic acid from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine, a precursor of platelet-activating factor, in rat alveolar macrophages.

Authors:  D H Albert; F Snyder
Journal:  Biochim Biophys Acta       Date:  1984-10-24

8.  1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187.

Authors:  C L Swendsen; J M Ellis; F H Chilton; J T O'Flaherty; R L Wykle
Journal:  Biochem Biophys Res Commun       Date:  1983-05-31       Impact factor: 3.575

9.  Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation.

Authors:  D H Albert; F Snyder
Journal:  J Biol Chem       Date:  1983-01-10       Impact factor: 5.157

10.  A role for the eosinophil in acquired resistance to Schistosoma mansoni infection as determined by antieosinophil serum.

Authors:  A A Mahmoud; K S Warren; P A Peters
Journal:  J Exp Med       Date:  1975-10-01       Impact factor: 14.307
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  10 in total

1.  MALDI imaging of lipid biochemistry in tissues by mass spectrometry.

Authors:  Karin A Zemski Berry; Joseph A Hankin; Robert M Barkley; Jeffrey M Spraggins; Richard M Caprioli; Robert C Murphy
Journal:  Chem Rev       Date:  2011-09-26       Impact factor: 60.622

Review 2.  The regulation and cellular functions of phosphatidylcholine hydrolysis.

Authors:  M M Billah; J C Anthes
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

3.  Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.

Authors:  Ying Lai; Rob C Oslund; James G Bollinger; William R Henderson; Luis F Santana; William A Altemeier; Michael H Gelb; Teal S Hallstrand
Journal:  J Biol Chem       Date:  2010-10-25       Impact factor: 5.157

Review 4.  Eosinophils: a review.

Authors:  B J McEwen
Journal:  Vet Res Commun       Date:  1992       Impact factor: 2.459

5.  Metabolic spectroscopy of inflammation in a bleomycin-induced lung injury model using hyperpolarized 1-(13) C pyruvate.

Authors:  Hoora Shaghaghi; Stephen Kadlecek; Charuhas Deshpande; Sarmad Siddiqui; Daniel Martinez; Mehrdad Pourfathi; Hooman Hamedani; Masaru Ishii; Harrilla Profka; Rahim Rizi
Journal:  NMR Biomed       Date:  2014-05-28       Impact factor: 4.044

6.  Characterization of platelet-activating factor synthesized by normal and granulocyte-macrophage colony-stimulating factor-primed human eosinophils.

Authors:  M Triggiani; R P Schleimer; K Tomioka; W C Hubbard; F H Chilton
Journal:  Immunology       Date:  1992-12       Impact factor: 7.397

7.  Production of platelet-activating factor by human normodense and hypodense eosinophils.

Authors:  A Ojima-Uchiyama; Y Masuzawa; T Sugiura; K Waku; T Fukuda; S Makino
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

Review 8.  Recent advances in our understanding of the biochemical interactions between platelet-activating factor and arachidonic acid.

Authors:  F H Chilton; M Cluzel; M Triggiani
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

Review 9.  Role for platelet-activating factor in asthma.

Authors:  K F Chung; P J Barnes
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

Review 10.  Coenzyme-A-Independent Transacylation System; Possible Involvement of Phospholipase A2 in Transacylation.

Authors:  Atsushi Yamashita; Yasuhiro Hayashi; Naoki Matsumoto; Yoko Nemoto-Sasaki; Takanori Koizumi; Yusuke Inagaki; Saori Oka; Takashi Tanikawa; Takayuki Sugiura
Journal:  Biology (Basel)       Date:  2017-03-30
  10 in total

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