Mengyu Fan1,2, Dianjianyi Sun1,2, Tao Zhou1, Yoriko Heianza1, Jun Lv2,3,4, Liming Li2, Lu Qi1,5. 1. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1724, New Orleans, LA 70112, USA. 2. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. 3. Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, 38 Xueyuan Road, Beijing 100191, China. 4. Peking University Institute of Environmental Medicine, 38 Xueyuan Road, Beijing 100191, China. 5. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA.
Abstract
AIMS: To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD). METHODS AND RESULTS: This study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7-8 h per day, never/rarely insomnia, no snoring, and no frequent excessive daytime sleepiness. Weighted genetic risk scores of coronary heart disease (CHD) or stroke were calculated. During a median of 8.5 years of follow-up, we documented 7280 incident CVD cases including 4667 CHD and 2650 stroke cases. Compared to those with a sleep score of 0-1, participants with a score of 5 had a 35% (19-48%), 34% (22-44%), and 34% (25-42%) reduced risk of CVD, CHD, and stroke, respectively. Nearly 10% of cardiovascular events in this cohort could be attributed to poor sleep pattern. Participants with poor sleep pattern and high genetic risk showed the highest risk of CHD and stroke. CONCLUSION: In this large prospective study, a healthy sleep pattern was associated with reduced risks of CVD, CHD, and stroke among participants with low, intermediate, or high genetic risk. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD). METHODS AND RESULTS: This study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7-8 h per day, never/rarely insomnia, no snoring, and no frequent excessive daytime sleepiness. Weighted genetic risk scores of coronary heart disease (CHD) or stroke were calculated. During a median of 8.5 years of follow-up, we documented 7280 incident CVD cases including 4667 CHD and 2650 stroke cases. Compared to those with a sleep score of 0-1, participants with a score of 5 had a 35% (19-48%), 34% (22-44%), and 34% (25-42%) reduced risk of CVD, CHD, and stroke, respectively. Nearly 10% of cardiovascular events in this cohort could be attributed to poor sleep pattern. Participants with poor sleep pattern and high genetic risk showed the highest risk of CHD and stroke. CONCLUSION: In this large prospective study, a healthy sleep pattern was associated with reduced risks of CVD, CHD, and stroke among participants with low, intermediate, or high genetic risk. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Christopher P Nelson; Anuj Goel; Adam S Butterworth; Stavroula Kanoni; Tom R Webb; Eirini Marouli; Lingyao Zeng; Ioanna Ntalla; Florence Y Lai; Jemma C Hopewell; Olga Giannakopoulou; Tao Jiang; Stephen E Hamby; Emanuele Di Angelantonio; Themistocles L Assimes; Erwin P Bottinger; John C Chambers; Robert Clarke; Colin N A Palmer; Richard M Cubbon; Patrick Ellinor; Raili Ermel; Evangelos Evangelou; Paul W Franks; Christopher Grace; Dongfeng Gu; Aroon D Hingorani; Joanna M M Howson; Erik Ingelsson; Adnan Kastrati; Thorsten Kessler; Theodosios Kyriakou; Terho Lehtimäki; Xiangfeng Lu; Yingchang Lu; Winfried März; Ruth McPherson; Andres Metspalu; Mar Pujades-Rodriguez; Arno Ruusalepp; Eric E Schadt; Amand F Schmidt; Michael J Sweeting; Pierre A Zalloua; Kamal AlGhalayini; Bernard D Keavney; Jaspal S Kooner; Ruth J F Loos; Riyaz S Patel; Martin K Rutter; Maciej Tomaszewski; Ioanna Tzoulaki; Eleftheria Zeggini; Jeanette Erdmann; George Dedoussis; Johan L M Björkegren; Heribert Schunkert; Martin Farrall; John Danesh; Nilesh J Samani; Hugh Watkins; Panos Deloukas Journal: Nat Genet Date: 2017-07-17 Impact factor: 38.330
Authors: Francesco Portaluppi; Ruana Tiseo; Michael H Smolensky; Ramón C Hermida; Diana E Ayala; Fabio Fabbian Journal: Sleep Med Rev Date: 2011-06-08 Impact factor: 11.609
Authors: Qibin Qi; Audrey Y Chu; Jae H Kang; Majken K Jensen; Gary C Curhan; Louis R Pasquale; Paul M Ridker; David J Hunter; Walter C Willett; Eric B Rimm; Daniel I Chasman; Frank B Hu; Lu Qi Journal: N Engl J Med Date: 2012-09-21 Impact factor: 91.245
Authors: Ilona Merikanto; Tuuli Lahti; Hannu Puolijoki; Mauno Vanhala; Markku Peltonen; Tiina Laatikainen; Erkki Vartiainen; Veikko Salomaa; Erkki Kronholm; Timo Partonen Journal: Chronobiol Int Date: 2013-01-02 Impact factor: 2.877
Authors: Tiange Wang; Yoriko Heianza; Dianjianyi Sun; Tao Huang; Wenjie Ma; Eric B Rimm; JoAnn E Manson; Frank B Hu; Walter C Willett; Lu Qi Journal: BMJ Date: 2018-01-10
Authors: Loes Ca Rutten-Jacobs; Susanna C Larsson; Rainer Malik; Kristiina Rannikmäe; Cathie L Sudlow; Martin Dichgans; Hugh S Markus; Matthew Traylor Journal: BMJ Date: 2018-10-24
Authors: Muhammed Lamin Sambou; Xiaoyu Zhao; Tongtong Hong; Muhammad Naveed; Alima Sambou; Fadoua El Hafa; TIl B Basnet; Juncheng Dai Journal: Sleep Breath Date: 2021-05-06 Impact factor: 2.816