Literature DB >> 31848534

Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin.

Zhen Jie Low1, Juan Xiong2, Ying Xie1, Guang-Lei Ma1, Howard Saw1, Hoa Thi Tran1, Soo Lin Wong1, Li Mei Pang1, July Fong3, Peng Lu1, Jin-Feng Hu4, Liang Yang5, Yansong Miao1, Zhao-Xun Liang6.   

Abstract

Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.

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Year:  2019        PMID： 31848534     DOI： 10.1039/c9cc08908j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Synthesis of the C1-C27 Fragment of Stambomycin D Validates Modular Polyketide Synthase-Based Stereochemical Assignments.

Authors:  Jieyan Lim; Venkaiah Chintalapudi; Haraldur G Gudmundsson; Minh Tran; Alice Bernasconi; Araceli Blanco; Lijiang Song; Gregory L Challis; Edward A Anderson
Journal:  Org Lett       Date:  2021-09-08       Impact factor: 6.005

2.  Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides.

Authors:  Xiaorui Guo; Jiabao Zhang; Xinyi Li; Emily Xiao; Justin D Lange; Chad M Rienstra; Martin D Burke; Douglas A Mitchell
Journal:  ACS Cent Sci       Date:  2021-04-26       Impact factor: 14.553

Review 3.  New Glycosylated Polyene Macrolides: Refining the Ore from Genome Mining.

Authors:  Patrick Caffrey; Mark Hogan; Yuhao Song
Journal:  Antibiotics (Basel)       Date:  2022-03-03
  3 in total

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