| Literature DB >> 31848114 |
Yuki Hitora1, Kentaro Takada2, Yuji Ise3, Sau Pinn Woo4, Seiya Inoue5, Naoki Mori5, Hirosato Takikawa5, Shohei Nakamukai1, Shigeru Okada1, Shigeki Matsunaga6.
Abstract
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.Entities:
Keywords: Cell-cycle; Marine sponge; Structure elucidation; Terpenoid
Year: 2019 PMID： 31848114 DOI： 10.1016/j.bmc.2019.115233
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641