Hiroaki Yaguchi1, Takahiro Tsuji2, Ichiro Yabe3, Emi Hirayama4, Taichi Nomura5, Ikkei Ohashi5, Yasunori Mito5, Keiko Tanaka6, Yasutaka Tajima5. 1. Department of Neurology, Brain Science Center, Sapporo City General Hospital, Sapporo, Japan; Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. Electronic address: yaguchi-h@pop.med.hokudai.ac.jp. 2. Department of Pathology, Sapporo City General Hospital, Sapporo, Japan. 3. Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan. 4. Department of Obstetrics and Gynecology, Sapporo City General Hospital, Sapporo, Japan. 5. Department of Neurology, Brain Science Center, Sapporo City General Hospital, Sapporo, Japan. 6. Department of Animal Model Development, Brain Research Institute, Niigata University, Japan.
Abstract
OBJECTIVE: The objective of this study was to determine the incidence of anti-NMDAR encephalitis in patients in whom a teratoma was removed. As far as we know, there has been no report on the incidence of anti-NMDAR encephalitis in patients in whom a teratoma was removed. METHODS: This study was a single-institutional observational study. We enrolled patients who were diagnosed with teratoma in the Department of Pathology, Sapporo City General Hospital during a nine-year period between January 2008 and December 2016. RESULTS: In Sapporo City General Hospital, 6 NMDAR encephalitis cases were detected during the 9-year period. In the same 9-year period, a pathological diagnosis of teratoma was made in 343 cases in the hospital. Anti-NMDAR encephalitis patients with a teratoma accounted for only 1.17% of all teratoma patients. Three of the 4 anti-NMDAR encephalitis patients with a teratoma underwent second removal of a teratoma, and no nervous tissue was detected pathologically. CONCLUSIONS: In this study, we determined the association between teratoma with anti-NMDAR encephalitis and teratoma without anti-NMDAR encephalitis in cases in a single institution. As far as we know, this report is the first report on the incidence of anti-NMDAR encephalitis in teratoma patients.
OBJECTIVE: The objective of this study was to determine the incidence of anti-NMDAR encephalitis in patients in whom a teratoma was removed. As far as we know, there has been no report on the incidence of anti-NMDAR encephalitis in patients in whom a teratoma was removed. METHODS: This study was a single-institutional observational study. We enrolled patients who were diagnosed with teratoma in the Department of Pathology, Sapporo City General Hospital during a nine-year period between January 2008 and December 2016. RESULTS: In Sapporo City General Hospital, 6 NMDAR encephalitis cases were detected during the 9-year period. In the same 9-year period, a pathological diagnosis of teratoma was made in 343 cases in the hospital. Anti-NMDAR encephalitispatients with a teratoma accounted for only 1.17% of all teratomapatients. Three of the 4 anti-NMDAR encephalitispatients with a teratoma underwent second removal of a teratoma, and no nervous tissue was detected pathologically. CONCLUSIONS: In this study, we determined the association between teratoma with anti-NMDAR encephalitis and teratoma without anti-NMDAR encephalitis in cases in a single institution. As far as we know, this report is the first report on the incidence of anti-NMDAR encephalitis in teratomapatients.