Jialing Peng1, Hongxuan Wang1, Xiaoming Rong1, Lei He1, L Xiangpen1, Qingy Shen1, Ying Peng1,2. 1. Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. No. 33 Yinfeng Road, Guangzhou 510828. 2. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. No. 33 Yinfeng Road, Guangzhou 510828.
Abstract
AIMS: To investigate the dose-response relationships between alcohol and intracerebral hemorrhage (ICH), the impact of alcohol on the outcome of ICH and possible mechanisms underlying hypertensive ICH (HICH) caused by heavy drinking. METHODS: Literature search from 1985 to August 2019 in the PubMed database. RESULTS: The relationship between low-middle alcohol consumption and ICH remains controversial for various reasons, whereas chronic heavy drinking increases the incidence of ICH and exerts worse outcome. More attention is needed to clarify the characteristics of chronic alcohol intake and binge drinking. Chronic alcohol abuse tends to elevates blood pressure, resulting in increased occurrence of HICH and exaggerated HICH-contributed brain injury. CONCLUSION: It is important to develop strategies to promote reasonable intake categories, prevent alcoholism and thus reduce the risk of ICH.
AIMS: To investigate the dose-response relationships between alcohol and intracerebral hemorrhage (ICH), the impact of alcohol on the outcome of ICH and possible mechanisms underlying hypertensive ICH (HICH) caused by heavy drinking. METHODS: Literature search from 1985 to August 2019 in the PubMed database. RESULTS: The relationship between low-middle alcohol consumption and ICH remains controversial for various reasons, whereas chronic heavy drinking increases the incidence of ICH and exerts worse outcome. More attention is needed to clarify the characteristics of chronic alcohol intake and binge drinking. Chronic alcohol abuse tends to elevates blood pressure, resulting in increased occurrence of HICH and exaggerated HICH-contributed brain injury. CONCLUSION: It is important to develop strategies to promote reasonable intake categories, prevent alcoholism and thus reduce the risk of ICH.