Ling Shi1, Yu Liu2, Jingxing Wang2, Peibin Zeng3, Zhan Gao2, Shaoli Wang2, Ping Fu2, Jing Liu4, Wei Mao5, Weilan He6, Hongli Ma7, Mei Huang8, Jianhua Wan9, Dan Liao10, Donald Brambilla10, Marian Sullivan10, Shimian Zou11, Paul Ness4, Miao He2, Hua Shan12. 1. University of Massachusetts at Boston, Boston, Massachusetts. 2. Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, P. R. China. 3. West China School of Public Health, Sichuan University, Chengdu, P. R. China. 4. The Johns Hopkins Medical Institutions, Baltimore, Maryland. 5. Chongqing Blood Center, Chongqing, China. 6. Guangxi Blood Center, Liuzhou, P. R. China. 7. Luoyang Blood Center, Luoyang, P. R. China. 8. Mianyang Blood Center, Mianyang, China. 9. Urumqi Blood Center, Urumqi, P. R. China. 10. RTI International, Rockville, Maryland. 11. National Heart, Lung, and Blood Institute, Bethesda, Maryland. 12. Stanford University, Stanford, California.
Abstract
BACKGROUND: Previous data, although scant, indicated that the incidence of HIV in China has increased over the past decade. There is a growing concern about the impact of the HIV epidemic on blood safety. METHODS AND MATERIALS: We used donation data from five geographically-disperse blood centers in 2013-2016 participating in the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) China program to estimate HIV prevalence and incidence among blood donors. Multivariable logistic regression model was used to examine factors associated with HIV infection in Chinese blood donors. RESULTS: The overall HIV prevalence among first-time donors from 2013 through 2016 was 68.04 per 100,000 donors (95% CI 61.68-74.40). The HIV incidence rate was estimated to be 37.93 per 100,000 person-years (95% CI 30.62-46.97) among first-time donors and 20.55 per 100,000 person-years (95% CI 16.95-24.91) among repeat donors. There was substantial variation in HIV prevalence and incidence rates across blood centers. Multivariable logistic regression results showed that among first-time donors, being male, older than 25 years, minority ethnicity, less than college education, and certain occupations (commercial services, factory workers, retired, unemployed, or self-employed) were associated with positive HIV confirmatory testing results. CONCLUSION: HIV prevalence and incidence among blood donors remain low in the selected five regions in China; however, an increasing trend is observed at some blood centers. It is important to monitor HIV epidemiology in Chinese blood donors on a continuous basis, especially among populations and regions of higher risk.
BACKGROUND: Previous data, although scant, indicated that the incidence of HIV in China has increased over the past decade. There is a growing concern about the impact of the HIV epidemic on blood safety. METHODS AND MATERIALS: We used donation data from five geographically-disperse blood centers in 2013-2016 participating in the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) China program to estimate HIV prevalence and incidence among blood donors. Multivariable logistic regression model was used to examine factors associated with HIV infection in Chinese blood donors. RESULTS: The overall HIV prevalence among first-time donors from 2013 through 2016 was 68.04 per 100,000 donors (95% CI 61.68-74.40). The HIV incidence rate was estimated to be 37.93 per 100,000 person-years (95% CI 30.62-46.97) among first-time donors and 20.55 per 100,000 person-years (95% CI 16.95-24.91) among repeat donors. There was substantial variation in HIV prevalence and incidence rates across blood centers. Multivariable logistic regression results showed that among first-time donors, being male, older than 25 years, minority ethnicity, less than college education, and certain occupations (commercial services, factory workers, retired, unemployed, or self-employed) were associated with positive HIV confirmatory testing results. CONCLUSION: HIV prevalence and incidence among blood donors remain low in the selected five regions in China; however, an increasing trend is observed at some blood centers. It is important to monitor HIV epidemiology in Chinese blood donors on a continuous basis, especially among populations and regions of higher risk.
Authors: Diep Ngoc Nguyen; Hai Minh Vu; Quang Nhat Nguyen; Cuong Tat Nguyen; Hoa Thi Do; Thuc Minh Thi Vu; Bach Xuan Tran; Carl A Latkin; Cyrus S H Ho; Roger C M Ho Journal: AIDS Behav Date: 2021-07-24