Literature DB >> 31844010

Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum Malaria.

José Luiz Fernandes Vieira1, Juan Gonzalo Bardalez Rivera2, Luann Wendel Pereira de Sena2, Michelle Valeria Dias Ferreira2.   

Abstract

Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significant associations between the total cholesterol or triglycerides with plasma concentrations of mefloquine and of carboxy-mefloquine. Lipoprotein levels explained 25.68% and 18.31% of mefloquine and carboxy-mefloquine plasma concentrations, respectively.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  infectious diseases; lipids; lipoproteins; malaria; mefloquine

Mesh：

Substances：

Year:  2020        PMID： 31844010      PMCID： PMC7038304          DOI： 10.1128/AAC.01731-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Food increases the bioavailability of mefloquine.

Authors:  C Crevoisier; J Handschin; J Barré; D Roumenov; C Kleinbloesem
Journal:  Eur J Clin Pharmacol       Date:  1997       Impact factor: 2.953

2.  Single dose kinetics of mefloquine in man. Plasma levels of the unchanged drug and of one of its metabolites.

Authors:  D E Schwartz; G Eckert; D Hartmann; B Weber; D Richard-Lenoble; J M Ekue; M Gentilini
Journal:  Chemotherapy       Date:  1982       Impact factor: 2.544

3.  Effect of altered serum lipid concentrations on the IC50 of halofantrine against Plasmodium falciparum.

Authors:  A J Humberstone; A F Cowman; J Horton; W N Charman
Journal:  J Pharm Sci       Date:  1998-02       Impact factor: 3.534

4.  Photoaffinity labeling of mefloquine-binding proteins in human serum, uninfected erythrocytes and Plasmodium falciparum-infected erythrocytes.

Authors:  J Desneves; G Thorn; A Berman; D Galatis; N La Greca; J Sinding; M Foley; L W Deady; A F Cowman; L Tilley
Journal:  Mol Biochem Parasitol       Date:  1996-11-25       Impact factor: 1.759

5.  High-performance liquid chromatographic separation and extraction investigation for the simultaneous determination of mefloquine and its carboxylic acid metabolite.

Authors:  Y Bergqvist; S Eckerbom; N Larsson; F C Churchill
Journal:  J Chromatogr       Date:  1988-06-03

6.  Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein.

Authors:  Ferenc Zsila; Júlia Visy; György Mády; Ilona Fitos
Journal:  Bioorg Med Chem       Date:  2008-02-02       Impact factor: 3.641

7.  The antimalarial drug mefloquine binds to membrane phospholipids.

Authors:  R Chevli; C D Fitch
Journal:  Antimicrob Agents Chemother       Date:  1982-04       Impact factor: 5.191

8.  Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile.

Authors:  Seth S Martin; Michael J Blaha; Mohamed B Elshazly; Peter P Toth; Peter O Kwiterovich; Roger S Blumenthal; Steven R Jones
Journal:  JAMA       Date:  2013-11-20       Impact factor: 56.272

Review 9.  Stereoselective binding of chiral drugs to plasma proteins.

Authors:  Qi Shen; Lu Wang; Hui Zhou; Hui-di Jiang; Lu-shan Yu; Su Zeng
Journal:  Acta Pharmacol Sin       Date:  2013-07-15       Impact factor: 6.150

10.  Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria.

Authors:  Julie Gutman; Michael Green; Salomon Durand; Ofelia Villalva Rojas; Babita Ganguly; Wilmer Marquiño Quezada; Gregory C Utz; Laurence Slutsker; Trenton K Ruebush; David J Bacon
Journal:  Malar J       Date:  2009-04-09       Impact factor: 2.979
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