Theodoros Karampitsakos1, Katerina Dimakou1, Ourania Papaioannou1, Serafeim Chrysikos1, Maria Kaponi1, Demosthenes Bouros2, Argyrios Tzouvelekis3, Georgios Hillas1. 1. 5th Pulmonary Department, "Sotiria" Chest Diseases Hospital, Athens, Greece. 2. 1st Academic Department of Pneumonology, Hospital for Thoracic Diseases, "Sotiria", Medical School, National and Kapodistrian University of Athens, Athens, Greece. 3. 1st Academic Department of Pneumonology, Hospital for Thoracic Diseases, "Sotiria", Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: argyrios.tzouvelekis@fleming.gr.
Abstract
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) remains a major burden with no clinically applicable biomarkers. AIM: To investigate the association of Red cell Distribution Width (RDW) values on admission with previous hospitalizations, need of non-invasive mechanical ventilation (NIMV) and long term oxygen therapy (LTOT) in patients with COPD. METHODS: Patients with AECOPD admitted to our department during 2018 were included in the study. RESULTS: One hundred sixty patients were enrolled (M/F 95/65, median age 71.00 years, mean FEV1± SD = 46.6 ± 28.9). Median RDW was significantly higher for patients in need of NIMV (14.8, 95% CI: 14.2 to 15.6) than patients not in need of NIMV (13.5, 95% CI: 13.2 to 13.8) (p < 0.001). Median RDW was significantly higher for patients in need of LTOT (14.2, 95% CI: 13.7 to 14.6) compared to patients not receiving LTOT (13.2, 95% CI: 12.5 to 13.6) (p = 0.001). Patients with hospitalization during the last 12 months had increased RDW values compared to patients with no hospitalizations [median RDW 14.3, (95% CI: 13.5 to 14.9) versus median RDW 13.5, (95% CI: 13.1 to 13.9)](p = 0.001). CONCLUSION: Patients with COPD in need of LTOT, NIMV or patients with previous hospitalizations presented with increased RDW values. Increased RDW values could serve as a negative prognostic marker in patients with COPD.
INTRODUCTION:Chronic obstructive pulmonary disease (COPD) remains a major burden with no clinically applicable biomarkers. AIM: To investigate the association of Red cell Distribution Width (RDW) values on admission with previous hospitalizations, need of non-invasive mechanical ventilation (NIMV) and long term oxygen therapy (LTOT) in patients with COPD. METHODS:Patients with AECOPD admitted to our department during 2018 were included in the study. RESULTS: One hundred sixty patients were enrolled (M/F 95/65, median age 71.00 years, mean FEV1± SD = 46.6 ± 28.9). Median RDW was significantly higher for patients in need of NIMV (14.8, 95% CI: 14.2 to 15.6) than patients not in need of NIMV (13.5, 95% CI: 13.2 to 13.8) (p < 0.001). Median RDW was significantly higher for patients in need of LTOT (14.2, 95% CI: 13.7 to 14.6) compared to patients not receiving LTOT (13.2, 95% CI: 12.5 to 13.6) (p = 0.001). Patients with hospitalization during the last 12 months had increased RDW values compared to patients with no hospitalizations [median RDW 14.3, (95% CI: 13.5 to 14.9) versus median RDW 13.5, (95% CI: 13.1 to 13.9)](p = 0.001). CONCLUSION:Patients with COPD in need of LTOT, NIMV or patients with previous hospitalizations presented with increased RDW values. Increased RDW values could serve as a negative prognostic marker in patients with COPD.
Keywords:
Biomarkers; Chronic obstructive pulmonary disease; Hospitalizations; Long term oxygen therapy; Non-invasive mechanical ventilation; Red cell distribution width
Authors: Bora E Baysal; Abdulrahman A Alahmari; Tori C Rodrick; Debra Tabaczynski; Leslie Curtin; Mukund Seshadri; Drew R Jones; Sandra Sexton Journal: JCI Insight Date: 2022-09-08