Yixiang Ng1, Lily Ai Vee Chua2, Lin Cui3, Li Wei Ang4, Nancy Wen Sim Tee3, Raymond Tzer Pin Lin3, Stefan Ma1, Vernon Jian Ming Lee5. 1. Epidemiology and Disease Control Division, Ministry of Health, Singapore. 2. Epidemiology and Disease Control Division, Ministry of Health, Singapore. Electronic address: Lily_Chua@moh.gov.sg. 3. National Public Health Laboratory, National Centre for Infectious Diseases, Singapore. 4. National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore. 5. Communicable Disease Division, Ministry of Health, Singapore.
Abstract
OBJECTIVES: The Ministry of Health (MOH), Singapore, conducted the National Paediatric Seroprevalence Survey 2018 (NPSS 2018) to estimate the latest immunity levels against measles, rubella, varicella, diphtheria, tetanus and hepatitis B, and the seroprevalence of chronic hepatitis B virus (HBV) carriage in children and adolescents in Singapore. METHODS: The survey involved prospective collection of residual sera from 1,200 children and adolescents aged 1-17 years in two public acute hospitals. Enzyme-linked immunosorbent assays (EIA) or plague reduction neutralisation tests (PRNT) were used to determine the seroprevalence of the vaccine-preventable diseases. RESULTS: Overall prevalence of measles and rubella antibodies among Singaporean children and adolescents aged 1-17 years were 98.2% (95% CI: 91.2-98.8%) and 94.8% (95% CI: 93.4-95.9%) respectively. 97.1% (95% CI: 96.0-97.9%) of subjects had at least basic protection against diphtheria, while 89.3% (95% CI: 87.5-91.0%) were protected against tetanus. The prevalence of chronic HBV carriage was 0.4% (95% CI: 0.2-1.0%), while 45.7% (95% CI: 42.9-48.5%) were immune against HBV. The seroprevalence for varicella antibodies was 52.9% (95% CI: 50.1-55.7%). Concordance between vaccination status and seroprevalence was observed for measles, rubella, diphtheria and tetanus. CONCLUSION: Singapore's children and adolescents are well-protected against measles, rubella, diphtheria and tetanus. Continual efforts in ensuring high vaccination coverage should be sustained.
OBJECTIVES: The Ministry of Health (MOH), Singapore, conducted the National Paediatric Seroprevalence Survey 2018 (NPSS 2018) to estimate the latest immunity levels against measles, rubella, varicella, diphtheria, tetanus and hepatitis B, and the seroprevalence of chronic hepatitis B virus (HBV) carriage in children and adolescents in Singapore. METHODS: The survey involved prospective collection of residual sera from 1,200 children and adolescents aged 1-17 years in two public acute hospitals. Enzyme-linked immunosorbent assays (EIA) or plague reduction neutralisation tests (PRNT) were used to determine the seroprevalence of the vaccine-preventable diseases. RESULTS: Overall prevalence of measles and rubella antibodies among Singaporean children and adolescents aged 1-17 years were 98.2% (95% CI: 91.2-98.8%) and 94.8% (95% CI: 93.4-95.9%) respectively. 97.1% (95% CI: 96.0-97.9%) of subjects had at least basic protection against diphtheria, while 89.3% (95% CI: 87.5-91.0%) were protected against tetanus. The prevalence of chronic HBV carriage was 0.4% (95% CI: 0.2-1.0%), while 45.7% (95% CI: 42.9-48.5%) were immune against HBV. The seroprevalence for varicella antibodies was 52.9% (95% CI: 50.1-55.7%). Concordance between vaccination status and seroprevalence was observed for measles, rubella, diphtheria and tetanus. CONCLUSION: Singapore's children and adolescents are well-protected against measles, rubella, diphtheria and tetanus. Continual efforts in ensuring high vaccination coverage should be sustained.
Authors: Anthony P Y Liu; Shui-Yen Soh; Frankie W C Cheng; Herbert H Pang; Chung-Wing Luk; Chak-Ho Li; Karin K H Ho; Edwin K W Chan; Albert C Y Chan; Patrick H Y Chung; Miriam S Kimpo; Summaiyya H Ahamed; Amos Loh; Alan K S Chiang Journal: Front Oncol Date: 2020-11-20 Impact factor: 6.244
Authors: Li Wei Ang; Qi Gao; Vernon Jian Ming Lee; Yee Sin Leo; Lin Cui; Aysha Farwin; Matthias Paul Han Sim Toh; Irving Charles Boudville; Mark I-Cheng Chen; Angela Chow; Raymond Tzer-Pin Lin Journal: BMC Infect Dis Date: 2022-01-25 Impact factor: 3.090