| Literature DB >> 31843430 |
Victor M Lu1, Oluwaseun O Akinduro2, David J Daniels3.
Abstract
A methionine substitution of lysine at residue 27 of histone H3 (H3K27M) mutation has become synonymous with malignant pediatric diffuse midline glioma (DMG), that occurs commonly in the brainstem. Therefore, recent reports that this same mutation occurs in malignant adult glioblastoma (GBM) located in the cerebellum are both unexpected and intriguing. The biological and clinical considerations of this novel finding are discussed.Entities:
Keywords: Adult; Cerebellum; Diffuse midline glioma; GBM; Glioblastoma; H3K27M
Year: 2019 PMID： 31843430 DOI： 10.1016/j.jocn.2019.11.016
Source DB: PubMed Journal: J Clin Neurosci ISSN： 0967-5868 Impact factor: 1.961