Literature DB >> 31843200

Aging, sex, inflammation, frailty, and CMV and HIV infections.

Sean X Leng1, Joseph B Margolick2.   

Abstract

Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline and increased vulnerability to infections, but also to play an important role in many chronic conditions such as frailty in older adults. In addition to sex as an important biological factor, chronic viral infections including that by human immunodeficiency virus (HIV) and cytomegalovirus (CMV) are all known to have major impact on the aging immune system. This article provides an overview of our current understanding of aging immunity, sex, inflammation, frailty, and HIV and CMV infections.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Aging; CLIP; CMV; Frailty; HIV; Immunosenescence; Sex

Mesh：

Year:  2019        PMID： 31843200      PMCID： PMC7002257          DOI： 10.1016/j.cellimm.2019.104024

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  76 in total

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Authors:  Sean X Leng; Tao Qu; Richard D Semba; Huifen Li; Xu Yao; Tricia Nilles; Xi Yang; Bhavish Manwani; Jeremy D Walston; Luigi Ferrucci; Linda P Fried; Joseph B Margolick; Jay H Bream
Journal:  Age (Dordr)       Date:  2011-01-28

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3.  Inflammation, Immune Activation, Immunosenescence, and Hormonal Biomarkers in the Frailty-Related Phenotype of Men With or at Risk for HIV Infection.

Authors:  Kristine M Erlandson; Derek K Ng; Lisa P Jacobson; Joseph B Margolick; Adrian S Dobs; Frank J Palella; Jordan E Lake; Hanhvy Bui; Lawrence Kingsley; Todd T Brown
Journal:  J Infect Dis       Date:  2017-01-15       Impact factor: 5.226

4.  Relationship Between T-Cell Responses to CMV, Markers of Inflammation, and Frailty in HIV-uninfected and HIV-infected Men in the Multicenter AIDS Cohort Study.

Authors:  Joseph B Margolick; Jay H Bream; Tricia L Nilles; Huifen Li; Susan J Langan; Shane Deng; Ruibin Wang; Nikolas Wada; Sean X Leng
Journal:  J Infect Dis       Date:  2018-06-20       Impact factor: 5.226

5.  Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women.

Authors:  Heidi N Schmaltz; Linda P Fried; Qian-Li Xue; Jeremy Walston; Sean X Leng; Richard D Semba
Journal:  J Am Geriatr Soc       Date:  2005-05       Impact factor: 5.562

Review 6.  Understanding frailty, aging, and inflammation in HIV infection.

Authors:  Sean X Leng; Joseph B Margolick
Journal:  Curr HIV/AIDS Rep       Date:  2015-03       Impact factor: 5.071

Review 7.  Adaptive reconfiguration of the human NK-cell compartment in response to cytomegalovirus: a different perspective of the host-pathogen interaction.

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9.  Quantification of Total and 2-LTR (Long terminal repeat) HIV DNA, HIV RNA and Herpesvirus DNA in PBMCs.

Authors:  Marta Massanella; Sara Gianella; Steven M Lada; Douglas D Richman; Matthew C Strain
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Journal:  J Exp Med       Date:  2005-09-05       Impact factor: 14.307
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Journal:  Nat Immunol       Date:  2020-11-09       Impact factor: 25.606

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Review 5.  Impact of sex and gender on COVID-19 outcomes in Europe.

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6.  Negative correlation between bone mineral density and subclinical fractures in patients with human immunodeficiency virus.

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9.  Influenza immunization among Chinese seniors: Urgent calling for improving vaccination coverage, education, and research.

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Review 10.  Role of Inflammasomes in HIV-1 and Drug Abuse Mediated Neuroinflammaging.

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Journal:  Cells       Date:  2020-08-08       Impact factor: 6.600
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