Literature DB >> 3184275

The E3 protein of bovine coronavirus is a receptor-destroying enzyme with acetylesterase activity.

R Vlasak1, W Luytjes, J Leider, W Spaan, P Palese.   

Abstract

In addition to members of the Orthomyxoviridae and Paramyxoviridae, several coronaviruses have been shown to possess receptor-destroying activities. Purified bovine coronavirus (BCV) preparations have an esterase activity which inactivates O-acetylsialic acid-containing receptors on erythrocytes. Diisopropyl fluorophosphate (DFP) completely inhibits this receptor-destroying activity of BCV, suggesting that the viral enzyme is a serine esterase. Treatment of purified BCV with [3H]DFP and subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the proteins revealed that the E3 protein was specifically phosphorylated. This finding suggests that the esterase/receptor-destroying activity of BCV is associated with the E3 protein. Furthermore, treatment of BCV with DFP dramatically reduced its infectivity in a plaque assay. It is assumed that the esterase activity of BCV is required in an early step of virus replication, possibly during virus entry or uncoating.

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Year:  1988        PMID： 3184275      PMCID： PMC253582     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

1.  Trypsin action on the growth of Sendai virus in tissue culture cells. 3. Structural difference of Sendai viruses grown in eggs and tissue culture cells.

Authors:  M Homma; M Ouchi
Journal:  J Virol       Date:  1973-12       Impact factor: 5.103

2.  Isolation and characterization of influenza virus recombinants with high and low neuraminidase activity. Use of 2-(3'-methoxyphenyl)-n-acetylneuraminic acid to identify cloned populations.

Authors:  P Palese; J Schulman
Journal:  Virology       Date:  1974-01       Impact factor: 3.616

3.  The hemagglutinating and neuraminidase protein of a paramyxovirus: interaction with neuraminic acid in affinity chromatography.

Authors:  A Scheid; P W Choppin
Journal:  Virology       Date:  1974-11       Impact factor: 3.616

4.  Isolation of paramyxovirus glycoproteins. Association of both hemagglutinating and neuraminidase activities with the larger SV5 glycoprotein.

Authors:  A Scheid; L A Caliguiri; R W Compans; P W Choppin
Journal:  Virology       Date:  1972-12       Impact factor: 3.616

5.  Characterization of temperature sensitive influenza virus mutants defective in neuraminidase.

Authors:  P Palese; K Tobita; M Ueda; R W Compans
Journal:  Virology       Date:  1974-10       Impact factor: 3.616

6.  Activation of precursors to both glycoporteins of Newcastle disease virus by proteolytic cleavage.

Authors:  Y Nagai; H D Klenk
Journal:  Virology       Date:  1977-03       Impact factor: 3.616

7.  Sequential passage of influenza virus in embryonated eggs or tissue culture: emergence of mutants.

Authors:  C Brand; P Palese
Journal:  Virology       Date:  1980-12       Impact factor: 3.616

8.  Bovine coronavirus structural proteins.

Authors:  B King; D A Brian
Journal:  J Virol       Date:  1982-05       Impact factor: 5.103

9.  Structural polypeptides of the murine coronavirus JHM.

Authors:  H Wege; H Wege; K Nagashima; V ter Meulen
Journal:  J Gen Virol       Date:  1979-01       Impact factor: 3.891

10.  Isolation and identification of virus-specific mRNAs in cells infected with mouse hepatitis virus (MHV-A59).

Authors:  W J Spaan; P J Rottier; M C Horzinek; B A van der Zeijst
Journal:  Virology       Date:  1981-01-30       Impact factor: 3.616
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  87 in total

Review 1.  Multifarious roles of sialic acids in immunity.

Authors:  Ajit Varki; Pascal Gagneux
Journal:  Ann N Y Acad Sci       Date:  2012-04       Impact factor: 5.691

2.  Attachment of mouse hepatitis virus to O-acetylated sialic acid is mediated by hemagglutinin-esterase and not by the spike protein.

Authors:  Martijn A Langereis; Arno L W van Vliet; Willemijn Boot; Raoul J de Groot
Journal:  J Virol       Date:  2010-06-10       Impact factor: 5.103

3.  Hemagglutinin-esterase-specific monoclonal antibodies alter the neuropathogenicity of mouse hepatitis virus.

Authors:  K Yokomori; S C Baker; S A Stohlman; M M Lai
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

Review 4.  RNA recombination in animal and plant viruses.

Authors:  M M Lai
Journal:  Microbiol Rev       Date:  1992-03

Review 5.  The molecular biology of coronaviruses.

Authors:  Paul S Masters
Journal:  Adv Virus Res       Date:  2006       Impact factor: 9.937

6.  Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia.

Authors:  Patrick C Y Woo; Susanna K P Lau; Chung-ming Chu; Kwok-hung Chan; Hoi-wah Tsoi; Yi Huang; Beatrice H L Wong; Rosana W S Poon; James J Cai; Wei-kwang Luk; Leo L M Poon; Samson S Y Wong; Yi Guan; J S Malik Peiris; Kwok-yung Yuen
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

7.  Comparison of hemagglutinating, receptor-destroying, and acetylesterase activities of avirulent and virulent bovine coronavirus strains.

Authors:  J Storz; X M Zhang; R Rott
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

8.  Bovine coronavirus antigen in the host cell plasmalemma.

Authors:  H R Payne; J Storz; W G Henk
Journal:  Exp Mol Pathol       Date:  1990-10       Impact factor: 3.362

9.  The S2 subunit of the spike glycoprotein of bovine coronavirus mediates membrane fusion in insect cells.

Authors:  D W Yoo; M D Parker; L A Babiuk
Journal:  Virology       Date:  1991-01       Impact factor: 3.616

10.  Induction of mucosal immunity in cotton rats to haemagglutinin-esterase glycoprotein of bovine coronavirus by recombinant adenovirus.

Authors:  M E Baca-Estrada; X Liang; L A Babiuk; D Yoo
Journal:  Immunology       Date:  1995-09       Impact factor: 7.397
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