Kasra Moazzami1, Matthew T Wittbrodt, Bruno B Lima, Oleksiy Levantsevych, Belal Kaseer, Afif Martini, Ammer Haffar, Jonathon A Nye, Arshed A Quyyumi, Amit Shah, Viola Vaccarino, J Douglas Bremner. 1. From the Department of Epidemiology (Moazzami, Lima, Levantsevych, Kaseer, Martini, Haffar, Shah, Vaccarino), Rollins School of Public Health, Emory University; Emory Clinical Cardiovascular Research Institute (Moazzami, Lima, Levantsevych, Kaseer, Martini, Haffar, Quyyumi, Shah, Vaccarino), Department of Medicine, Division of Cardiology, Emory University School of Medicine; Department of Psychiatry and Behavioral Sciences (Wittbrodt, Bremner), and Department of Radiology and Imaging Sciences (Nye, Bremner), Emory University School of Medicine, Atlanta; and Atlanta VA Medical Center (Shah, Bremner), Decatur, Gerogia.
Abstract
OBJECTIVE: This study aimed to investigate the relationship between waist circumference as a measure of abdominal obesity and brain responses to stress among patients with coronary artery disease (CAD). METHODS: Patients with CAD (N = 151) underwent acute mental stress tasks in conjunction with high-resolution positron emission tomography and radiolabeled water imaging of the brain. Brain responses to mental stress were correlated with waist circumference. RESULTS: Waist circumference was positively correlated with increased activation in the right and left frontal lobes (β values ranging from 2.81 to 3.75 in the paracentral, medial, and superior gyri), left temporal lobe, left hippocampal, left amygdala, left uncus, and left anterior and posterior cingulate gyri (β values ranging from 2.93 to 3.55). Waist circumference was also negatively associated with the left and right parietal lobes, right superior temporal gyrus, and right insula and precuneus (β values ranging from 2.82 to 5.20). CONCLUSION: Increased brain activation in the brain regions involved in the stress response and autonomic regulation of the cardiovascular system during psychological stress may underlie stress-induced overeating and abdominal obesity in patients with CAD.
OBJECTIVE: This study aimed to investigate the relationship between waist circumference as a measure of abdominal obesity and brain responses to stress among patients with coronary artery disease (CAD). METHODS: Patients with CAD (N = 151) underwent acute mental stress tasks in conjunction with high-resolution positron emission tomography and radiolabeled water imaging of the brain. Brain responses to mental stress were correlated with waist circumference. RESULTS: Waist circumference was positively correlated with increased activation in the right and left frontal lobes (β values ranging from 2.81 to 3.75 in the paracentral, medial, and superior gyri), left temporal lobe, left hippocampal, left amygdala, left uncus, and left anterior and posterior cingulate gyri (β values ranging from 2.93 to 3.55). Waist circumference was also negatively associated with the left and right parietal lobes, right superior temporal gyrus, and right insula and precuneus (β values ranging from 2.82 to 5.20). CONCLUSION: Increased brain activation in the brain regions involved in the stress response and autonomic regulation of the cardiovascular system during psychological stress may underlie stress-induced overeating and abdominal obesity in patients with CAD.
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Authors: Kasra Moazzami; Matthew T Wittbrodt; Bruno B Lima; Jeong Hwan Kim; Zakaria Almuwaqqat; Amit J Shah; Ihab Hajjar; Felicia C Goldstein; Allan I Levey; Jonathon A Nye; J Douglas Bremner; Viola Vaccarino; Arshed A Quyyumi Journal: J Alzheimers Dis Rep Date: 2021-02-02