Literature DB >> 31841858

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs.

Ines Carqueijeiro1, Chloe Langley2, Dagny Grzech2, Konstantinos Koudounas1, Nicolas Papon3, Sarah E O'Connor4, Vincent Courdavault5.   

Abstract

The discovery and supply of plant-derived anti-cancer compounds remain challenging given their low bioavailability and structural complexity. Reconstituting the pathways of these compounds in heterologous hosts is a promising solution; however, requires the complete elucidation of the biosynthetic genes involved and extensive metabolic engineering to optimise enzyme activity and metabolic flux. This review describes the current strategies and recent advancements in the production of these valuable therapeutic compounds, and highlights plant-derived immunomodulators as an emerging class of anti-cancer agents.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Year:  2019        PMID： 31841858     DOI： 10.1016/j.copbio.2019.11.017

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  11 in total

Review 1.  Addressing artifacts of colorimetric anticancer assays for plant-based drug development.

Authors:  Salma Batool; Seejal Javaid; Hira Javed; Izzah Shahid; Mishal Khan; Amna Muhammad
Journal:  Med Oncol       Date:  2022-09-07       Impact factor: 3.738

2.  Metabolomics-guided discovery of cytochrome P450s involved in pseudotropine-dependent biosynthesis of modified tropane alkaloids.

Authors:  Radin Sadre; Thilani M Anthony; Josh M Grabar; Matthew A Bedewitz; A Daniel Jones; Cornelius S Barry
Journal:  Nat Commun       Date:  2022-07-02       Impact factor: 17.694

3.  Antitumor Effects of Carvacrol and Thymol: A Systematic Review.

Authors:  Laeza Alves Sampaio; Lícia Tairiny Santos Pina; Mairim Russo Serafini; Débora Dos Santos Tavares; Adriana Gibara Guimarães
Journal:  Front Pharmacol       Date:  2021-07-07       Impact factor: 5.810

4.  Cellular and Subcellular Compartmentation of the 2C-Methyl-D-Erythritol 4-Phosphate Pathway in the Madagascar Periwinkle.

Authors:  Grégory Guirimand; Anthony Guihur; Catalina Perello; Michael Phillips; Samira Mahroug; Audrey Oudin; Thomas Dugé de Bernonville; Sébastien Besseau; Arnaud Lanoue; Nathalie Giglioli-Guivarc'h; Nicolas Papon; Benoit St-Pierre; Manuel Rodríguez-Concepcíon; Vincent Burlat; Vincent Courdavault
Journal:  Plants (Basel)       Date:  2020-04-07

5.  Identifying Genes Involved in alkaloid Biosynthesis in Vinca minor Through Transcriptomics and Gene Co-Expression Analysis.

Authors:  Emily Amor Stander; Liuda Johana Sepúlveda; Thomas Dugé de Bernonville; Inês Carqueijeiro; Konstantinos Koudounas; Pamela Lemos Cruz; Sébastien Besseau; Arnaud Lanoue; Nicolas Papon; Nathalie Giglioli-Guivarc'h; Ron Dirks; Sarah Ellen O'Connor; Lucia Atehortùa; Audrey Oudin; Vincent Courdavault
Journal:  Biomolecules       Date:  2020-11-24

6.  Determination of the Qualitative Composition of Biologically-Active Substances of Extracts of In Vitro Callus, Cell Suspension, and Root Cultures of the Medicinal Plant Rhodiola rosea.

Authors:  Lyudmila Asyakina; Stanislav Sukhikh; Svetlana Ivanova; Alexander Prosekov; Elena Ulrikh; Evgeny Chupahin; Olga Babich
Journal:  Biomolecules       Date:  2021-02-27

7.  CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an L-proline exporter for L-proline hyperproduction.

Authors:  Jiao Liu; Moshi Liu; Tuo Shi; Guannan Sun; Ning Gao; Xiaojia Zhao; Xuan Guo; Xiaomeng Ni; Qianqian Yuan; Jinhui Feng; Zhemin Liu; Yanmei Guo; Jiuzhou Chen; Yu Wang; Ping Zheng; Jibin Sun
Journal:  Nat Commun       Date:  2022-02-16       Impact factor: 17.694

Review 8.  Role of gut microbiota in identification of novel TCM-derived active metabolites.

Authors:  Tzu-Lung Lin; Chia-Chen Lu; Wei-Fan Lai; Ting-Shu Wu; Jang-Jih Lu; Young-Mao Chen; Chi-Meng Tzeng; Hong-Tao Liu; Hong Wei; Hsin-Chih Lai
Journal:  Protein Cell       Date:  2020-09-15       Impact factor: 14.870

Review 9.  Recent trends in biocatalysis.

Authors:  Dong Yi; Thomas Bayer; Christoffel P S Badenhorst; Shuke Wu; Mark Doerr; Matthias Höhne; Uwe T Bornscheuer
Journal:  Chem Soc Rev       Date:  2021-06-18       Impact factor: 60.615

Review 10.  A roadmap to engineering antiviral natural products synthesis in microbes.

Authors:  Jingbo Ma; Yang Gu; Peng Xu
Journal:  Curr Opin Biotechnol       Date:  2020-08-11       Impact factor: 9.740
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