Xin Yang1, Goska Leslie1, Alicja Doroszuk2, Sandra Schneider2, Jamie Allen1, Brennan Decker1,3,4, Alison M Dunning5, James Redman2, James Scarth2, Inga Plaskocinska2, Craig Luccarini5, Mitul Shah5, Karen Pooley1, Leila Dorling1, Andrew Lee1, Muriel A Adank6, Julian Adlard7, Kristiina Aittomäki8, Irene L Andrulis9, Peter Ang10, Julian Barwell11, Jonine L Bernstein12, Kristie Bobolis13, Åke Borg14, Carl Blomqvist15, Kathleen B M Claes16, Patrick Concannon17, Adeline Cuggia18,19, Julie O Culver20, Francesca Damiola21, Antoine de Pauw22, Orland Diez23, Jill S Dolinsky24, Susan M Domchek25,26, Christoph Engel27, D Gareth Evans28, Florentia Fostira29, Judy Garber26,30, Lisa Golmard22, Ellen L Goode31, Stephen B Gruber32, Eric Hahnen33,34, Christopher Hake13, Tuomas Heikkinen35, Judith E Hurley36, Ramunas Janavicius37,38, Zdenek Kleibl39, Petra Kleiblova39,40, Irene Konstantopoulou29, Anders Kvist14, Holly Laduca24, Ann S G Lee11,41,42, Fabienne Lesueur43, Eamonn R Maher2, Arto Mannermaa44, Siranoush Manoukian45, Rachel McFarland24,46, Wendy McKinnon47, Alfons Meindl48, Kelly Metcalfe49, Nur Aishah Mohd Taib50, Jukka Moilanen51, Katherine L Nathanson25, Susan Neuhausen52, Pei Sze Ng50,53, Tu Nguyen-Dumont54,55, Sarah M Nielsen56, Florian Obermair57, Kenneth Offit26,58, Olufunmilayo I Olopade56, Laura Ottini59, Judith Penkert60, Katri Pylkäs61, Paolo Radice62, Susan J Ramus63,64, Vilius Rudaitis37, Lucy Side65, Rachel Silva-Smith66, Valentina Silvestri59, Anne-Bine Skytte67, Thomas Slavin13,68, Jana Soukupova39, Carlo Tondini69, Alison H Trainer70,71, Gary Unzeitig13, Lydia Usha13, Thomas van Overeem Hansen72,73, James Whitworth2, Marie Wood47, Cheng Har Yip53, Sook-Yee Yoon53, Amal Yussuf24, George Zogopoulos18,19, David Goldgar74, John L Hopper75, Georgia Chenevix-Trench76, Paul Pharoah1, Sophia H L George77, Judith Balmaña23,26, Claude Houdayer22,78, Paul James70,71, Zaki El-Haffaf79, Hans Ehrencrona80,81, Marketa Janatova39, Paolo Peterlongo82, Heli Nevanlinna35, Rita Schmutzler33,34, Soo-Hwang Teo50,53, Mark Robson26,83, Tuya Pal84, Fergus Couch26,85, Jeffrey N Weitzel13,68, Aaron Elliott24, Melissa Southey54,55, Robert Winqvist61, Douglas F Easton1, William D Foulkes18,86, Antonis C Antoniou1, Marc Tischkowitz2. 1. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. 2. Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom. 3. Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. 4. Department of Pathology, Brigham and Women's Hospital, Boston, MA. 5. Centre for Cancer Genetic Epidemiology, Department of Oncology,University of Cambridge, Cambridge, United Kingdom. 6. Family Cancer Clinic, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. 7. Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom. 8. Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 9. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. 10. Laboratory of Molecular Oncology, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore. 11. Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom. 12. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY. 13. Clinical Cancer Genomics Community Research Network, City of Hope, Duarte, CA. 14. Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. 15. Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 16. Centre for Medical Genetics, Ghent University, Ghent, Belgium. 17. University of Florida Genetics Institute, University of Florida, Gainesville, FL. 18. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. 19. The Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. 20. Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA. 21. Biopathologie, Centre Léon Bérard, Lyon, France. 22. Service de Génétique, Institut Curie, Paris, France. 23. Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Barcelona, Spain. 24. Ambry Genetics, Aliso Viejo, CA. 25. Department ofMedicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. 26. Prospective Registry of Multiplex Testing (PROMPT), United States and Europe. 27. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 28. Division of Evolution and Genomic Sciences, University of Manchester; Manchester Centre for Genomic Medicine, St Mary's Hospital-Manchester University Hospitals NHS Foundation Trust; and Manchester Academic Health Science Centre, Manchester, United Kingdom. 29. Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos," Athens, Greece. 30. Dana-Farber Cancer Institute, Boston, MA. 31. Department of Health Sciences Research, Mayo Clinic, Rochester, MN. 32. City of Hope National Medical Center, Duarte, CA. 33. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. 34. Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany. 35. Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 36. Division of Medical Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL. 37. Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. 38. State Research Institute Innovative Medicine Center, Vilnius, Lithuania. 39. Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. 40. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic. 41. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 42. SingHealth Duke-NUS Oncology Academic Clinical Programme (ONCO ACP), Duke-NUS Medical School, Singapore. 43. INSERM U900, Institut Curie, PSL University, Mines ParisTech, Paris, France. 44. Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland. 45. Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 46. Department of Epidemiology, University of California, Irvine, Irvine, CA. 47. Familial Cancer Program, The University of Vermont Cancer Center, Burlington, VT. 48. Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Munich, Germany. 49. Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada. 50. University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. 51. Department of Clinical Genetics, Oulu University Hospital, Medical Research Center Oulu and PEDEGO Research Unit, University of Oulu, Oulu, Finland. 52. Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA. 53. Cancer Research Malaysia, Subang Jaya Selangor, Malaysia. 54. Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia. 55. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. 56. Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL. 57. Institute of Medical Genetics, Kepler University Hospital Linz and Laboratory for Molecular Biology and Tumor Cytogenetics, Ordensklinikum Linz, Linz, Austria. 58. Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. 59. Department of Molecular Medicine, University La Sapienza, Rome, Italy. 60. Department of Human Genetics, Hannover Medical School, Hannover, Germany. 61. Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre, Oulu, Finland. 62. Unit of Molecular Basis of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 63. School of Women's and Children's Health, Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia. 64. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia. 65. Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom. 66. Department of Genetics, University of MiamiMiller School of Medicine, Miami, FL. 67. Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark. 68. Department of Medical Oncology, Division of Clinical Cancer Genomics, City of Hope, Duarte, CA. 69. Unit of Medical Oncology, Department of Oncology and Hematology,Papa Giovanni XXIII Hospital, Bergamo, Italy. 70. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. 71. Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 72. Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 73. Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 74. Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT. 75. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. 76. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 77. Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL. 78. Genetics Department, F76000 and Normandy University, UNIROUEN, INSERM U1245, Normandy Centre for Genomic and Personalized Medicine, Rouen University Hospital, Rouen, France. 79. Department of Genetics, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada. 80. Department of Clinical Genetics and Pathology, Department of Laboratory Medicine, Office for Medical Services, Lund, Sweden. 81. Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. 82. Genome Diagnostics Program, IFOM-The FIRC Institute for Molecular Oncology, Milan, Italy. 83. Breast Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. 84. Vanderbilt-Ingram Cancer Center, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. 85. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. 86. Departments of Human Genetics, Oncology, and Medicine, McGill University, Montreal, Quebec, Canada.
Abstract
PURPOSE: To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS: We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis was used to estimate relative risks (RRs; relative to country-specific population incidences) and absolute risks of cancers. The models allowed for residual familial aggregation of breast and ovarian cancer and were adjusted for the family-specific ascertainment schemes. RESULTS: We found associations between PALB2 PVs and risk of female breast cancer (RR, 7.18; 95% CI, 5.82 to 8.85; P = 6.5 × 10-76), ovarian cancer (RR, 2.91; 95% CI, 1.40 to 6.04; P = 4.1 × 10-3), pancreatic cancer (RR, 2.37; 95% CI, 1.24 to 4.50; P = 8.7 × 10-3), and male breast cancer (RR, 7.34; 95% CI, 1.28 to 42.18; P = 2.6 × 10-2). There was no evidence for increased risks of prostate or colorectal cancer. The breast cancer RRs declined with age (P for trend = 2.0 × 10-3). After adjusting for family ascertainment, breast cancer risk estimates on the basis of multiple case families were similar to the estimates from families ascertained through population-based studies (P for difference = .41). On the basis of the combined data, the estimated risks to age 80 years were 53% (95% CI, 44% to 63%) for female breast cancer, 5% (95% CI, 2% to 10%) for ovarian cancer, 2%-3% (95% CI females, 1% to 4%; 95% CI males, 2% to 5%) for pancreatic cancer, and 1% (95% CI, 0.2% to 5%) for male breast cancer. CONCLUSION: These results confirm PALB2 as a major breast cancer susceptibility gene and establish substantial associations between germline PALB2 PVs and ovarian, pancreatic, and male breast cancers. These findings will facilitate incorporation of PALB2 into risk prediction models and optimize the clinical cancer risk management of PALB2 PV carriers.
PURPOSE: To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS: We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis was used to estimate relative risks (RRs; relative to country-specific population incidences) and absolute risks of cancers. The models allowed for residual familial aggregation of breast and ovarian cancer and were adjusted for the family-specific ascertainment schemes. RESULTS: We found associations between PALB2 PVs and risk of female breast cancer (RR, 7.18; 95% CI, 5.82 to 8.85; P = 6.5 × 10-76), ovarian cancer (RR, 2.91; 95% CI, 1.40 to 6.04; P = 4.1 × 10-3), pancreatic cancer (RR, 2.37; 95% CI, 1.24 to 4.50; P = 8.7 × 10-3), and male breast cancer (RR, 7.34; 95% CI, 1.28 to 42.18; P = 2.6 × 10-2). There was no evidence for increased risks of prostate or colorectal cancer. The breast cancer RRs declined with age (P for trend = 2.0 × 10-3). After adjusting for family ascertainment, breast cancer risk estimates on the basis of multiple case families were similar to the estimates from families ascertained through population-based studies (P for difference = .41). On the basis of the combined data, the estimated risks to age 80 years were 53% (95% CI, 44% to 63%) for female breast cancer, 5% (95% CI, 2% to 10%) for ovarian cancer, 2%-3% (95% CI females, 1% to 4%; 95% CI males, 2% to 5%) for pancreatic cancer, and 1% (95% CI, 0.2% to 5%) for male breast cancer. CONCLUSION: These results confirm PALB2 as a major breast cancer susceptibility gene and establish substantial associations between germline PALB2 PVs and ovarian, pancreatic, and male breast cancers. These findings will facilitate incorporation of PALB2 into risk prediction models and optimize the clinical cancer risk management of PALB2 PV carriers.
Authors: Tom Walsh; Silvia Casadei; Ming K Lee; Christopher C Pennil; Alex S Nord; Anne M Thornton; Wendy Roeb; Kathy J Agnew; Sunday M Stray; Anneka Wickramanayake; Barbara Norquist; Kathryn P Pennington; Rochelle L Garcia; Mary-Claire King; Elizabeth M Swisher Journal: Proc Natl Acad Sci U S A Date: 2011-10-17 Impact factor: 11.205
Authors: Matthew B Yurgelun; Matthew H Kulke; Charles S Fuchs; Brian A Allen; Hajime Uno; Jason L Hornick; Chinedu I Ukaegbu; Lauren K Brais; Philip G McNamara; Robert J Mayer; Deborah Schrag; Jeffrey A Meyerhardt; Kimmie Ng; John Kidd; Nanda Singh; Anne-Renee Hartman; Richard J Wenstrup; Sapna Syngal Journal: J Clin Oncol Date: 2017-01-30 Impact factor: 44.544
Authors: Siân Jones; Ralph H Hruban; Mihoko Kamiyama; Michael Borges; Xiaosong Zhang; D Williams Parsons; Jimmy Cheng-Ho Lin; Emily Palmisano; Kieran Brune; Elizabeth M Jaffee; Christine A Iacobuzio-Donahue; Anirban Maitra; Giovanni Parmigiani; Scott E Kern; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; James R Eshleman; Michael Goggins; Alison P Klein Journal: Science Date: 2009-03-05 Impact factor: 47.728
Authors: Rachel Pearlman; Wendy L Frankel; Benjamin Swanson; Weiqiang Zhao; Ahmet Yilmaz; Kristin Miller; Jason Bacher; Christopher Bigley; Lori Nelsen; Paul J Goodfellow; Richard M Goldberg; Electra Paskett; Peter G Shields; Jo L Freudenheim; Peter P Stanich; Ilene Lattimer; Mark Arnold; Sandya Liyanarachchi; Matthew Kalady; Brandie Heald; Carla Greenwood; Ian Paquette; Marla Prues; David J Draper; Carolyn Lindeman; J Philip Kuebler; Kelly Reynolds; Joanna M Brell; Amy A Shaper; Sameer Mahesh; Nicole Buie; Kisa Weeman; Kristin Shine; Mitchell Haut; Joan Edwards; Shyamal Bastola; Karen Wickham; Karamjit S Khanduja; Rosemary Zacks; Colin C Pritchard; Brian H Shirts; Angela Jacobson; Brian Allen; Albert de la Chapelle; Heather Hampel Journal: JAMA Oncol Date: 2017-04-01 Impact factor: 31.777
Authors: Marc Tischkowitz; Bing Xia; Nelly Sabbaghian; Jorge S Reis-Filho; Nancy Hamel; Guilan Li; Erik H van Beers; Lili Li; Tayma Khalil; Louise A Quenneville; Atilla Omeroglu; Aletta Poll; Pierre Lepage; Nora Wong; Petra M Nederlof; Alan Ashworth; Patricia N Tonin; Steven A Narod; David M Livingston; William D Foulkes Journal: Proc Natl Acad Sci U S A Date: 2007-04-09 Impact factor: 11.205
Authors: Antonis C Antoniou; Silvia Casadei; Tuomas Heikkinen; Daniel Barrowdale; Katri Pylkäs; Jonathan Roberts; Andrew Lee; Deepak Subramanian; Kim De Leeneer; Florentia Fostira; Eva Tomiak; Susan L Neuhausen; Zhi L Teo; Sofia Khan; Kristiina Aittomäki; Jukka S Moilanen; Clare Turnbull; Sheila Seal; Arto Mannermaa; Anne Kallioniemi; Geoffrey J Lindeman; Saundra S Buys; Irene L Andrulis; Paolo Radice; Carlo Tondini; Siranoush Manoukian; Amanda E Toland; Penelope Miron; Jeffrey N Weitzel; Susan M Domchek; Bruce Poppe; Kathleen B M Claes; Drakoulis Yannoukakos; Patrick Concannon; Jonine L Bernstein; Paul A James; Douglas F Easton; David E Goldgar; John L Hopper; Nazneen Rahman; Paolo Peterlongo; Heli Nevanlinna; Mary-Claire King; Fergus J Couch; Melissa C Southey; Robert Winqvist; William D Foulkes; Marc Tischkowitz Journal: N Engl J Med Date: 2014-08-07 Impact factor: 91.245
Authors: Melissa C Southey; David E Goldgar; Robert Winqvist; Katri Pylkäs; Fergus Couch; Marc Tischkowitz; William D Foulkes; Joe Dennis; Kyriaki Michailidou; Elizabeth J van Rensburg; Tuomas Heikkinen; Heli Nevanlinna; John L Hopper; Thilo Dörk; Kathleen Bm Claes; Jorge Reis-Filho; Zhi Ling Teo; Paolo Radice; Irene Catucci; Paolo Peterlongo; Helen Tsimiklis; Fabrice A Odefrey; James G Dowty; Marjanka K Schmidt; Annegien Broeks; Frans B Hogervorst; Senno Verhoef; Jane Carpenter; Christine Clarke; Rodney J Scott; Peter A Fasching; Lothar Haeberle; Arif B Ekici; Matthias W Beckmann; Julian Peto; Isabel Dos-Santos-Silva; Olivia Fletcher; Nichola Johnson; Manjeet K Bolla; Elinor J Sawyer; Ian Tomlinson; Michael J Kerin; Nicola Miller; Federik Marme; Barbara Burwinkel; Rongxi Yang; Pascal Guénel; Thérèse Truong; Florence Menegaux; Marie Sanchez; Stig Bojesen; Sune F Nielsen; Henrik Flyger; Javier Benitez; M Pilar Zamora; Jose Ignacio Arias Perez; Primitiva Menéndez; Hoda Anton-Culver; Susan Neuhausen; Argyrios Ziogas; Christina A Clarke; Hermann Brenner; Volker Arndt; Christa Stegmaier; Hiltrud Brauch; Thomas Brüning; Yon-Dschun Ko; Taru A Muranen; Kristiina Aittomäki; Carl Blomqvist; Natalia V Bogdanova; Natalia N Antonenkova; Annika Lindblom; Sara Margolin; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Amanda B Spurdle; kConFab Investigators; Els Wauters; Dominiek Smeets; Benoit Beuselinck; Giuseppe Floris; Jenny Chang-Claude; Anja Rudolph; Petra Seibold; Dieter Flesch-Janys; Janet E Olson; Celine Vachon; Vernon S Pankratz; Catriona McLean; Christopher A Haiman; Brian E Henderson; Fredrick Schumacher; Loic Le Marchand; Vessela Kristensen; Grethe Grenaker Alnæs; Wei Zheng; David J Hunter; Sara Lindstrom; Susan E Hankinson; Peter Kraft; Irene Andrulis; Julia A Knight; Gord Glendon; Anna Marie Mulligan; Arja Jukkola-Vuorinen; Mervi Grip; Saila Kauppila; Peter Devilee; Robert A E M Tollenaar; Caroline Seynaeve; Antoinette Hollestelle; Montserrat Garcia-Closas; Jonine Figueroa; Stephen J Chanock; Jolanta Lissowska; Kamila Czene; Hatef Darabi; Mikael Eriksson; Diana M Eccles; Sajjad Rafiq; William J Tapper; Sue M Gerty; Maartje J Hooning; John W M Martens; J Margriet Collée; Madeleine Tilanus-Linthorst; Per Hall; Jingmei Li; Judith S Brand; Keith Humphreys; Angela Cox; Malcolm W R Reed; Craig Luccarini; Caroline Baynes; Alison M Dunning; Ute Hamann; Diana Torres; Hans Ulrich Ulmer; Thomas Rüdiger; Anna Jakubowska; Jan Lubinski; Katarzyna Jaworska; Katarzyna Durda; Susan Slager; Amanda E Toland; Christine B Ambrosone; Drakoulis Yannoukakos; Anthony Swerdlow; Alan Ashworth; Nick Orr; Michael Jones; Anna González-Neira; Guillermo Pita; M Rosario Alonso; Nuria Álvarez; Daniel Herrero; Daniel C Tessier; Daniel Vincent; Francois Bacot; Jacques Simard; Martine Dumont; Penny Soucy; Rosalind Eeles; Kenneth Muir; Fredrik Wiklund; Henrik Gronberg; Johanna Schleutker; Børge G Nordestgaard; Maren Weischer; Ruth C Travis; David Neal; Jenny L Donovan; Freddie C Hamdy; Kay-Tee Khaw; Janet L Stanford; William J Blot; Stephen Thibodeau; Daniel J Schaid; Joseph L Kelley; Christiane Maier; Adam S Kibel; Cezary Cybulski; Lisa Cannon-Albright; Katja Butterbach; Jong Park; Radka Kaneva; Jyotsna Batra; Manuel R Teixeira; Zsofia Kote-Jarai; Ali Amin Al Olama; Sara Benlloch; Stefan P Renner; Arndt Hartmann; Alexander Hein; Matthias Ruebner; Diether Lambrechts; Els Van Nieuwenhuysen; Ignace Vergote; Sandrina Lambretchs; Jennifer A Doherty; Mary Anne Rossing; Stefan Nickels; Ursula Eilber; Shan Wang-Gohrke; Kunle Odunsi; Lara E Sucheston-Campbell; Grace Friel; Galina Lurie; Jeffrey L Killeen; Lynne R Wilkens; Marc T Goodman; Ingo Runnebaum; Peter A Hillemanns; Liisa M Pelttari; Ralf Butzow; Francesmary Modugno; Robert P Edwards; Roberta B Ness; Kirsten B Moysich; Andreas du Bois; Florian Heitz; Philipp Harter; Stefan Kommoss; Beth Y Karlan; Christine Walsh; Jenny Lester; Allan Jensen; Susanne Krüger Kjaer; Estrid Høgdall; Bernard Peissel; Bernardo Bonanni; Loris Bernard; Ellen L Goode; Brooke L Fridley; Robert A Vierkant; Julie M Cunningham; Melissa C Larson; Zachary C Fogarty; Kimberly R Kalli; Dong Liang; Karen H Lu; Michelle A T Hildebrandt; Xifeng Wu; Douglas A Levine; Fanny Dao; Maria Bisogna; Andrew Berchuck; Edwin S Iversen; Jeffrey R Marks; Lucy Akushevich; Daniel W Cramer; Joellen Schildkraut; Kathryn L Terry; Elizabeth M Poole; Meir Stampfer; Shelley S Tworoger; Elisa V Bandera; Irene Orlow; Sara H Olson; Line Bjorge; Helga B Salvesen; Anne M van Altena; Katja K H Aben; Lambertus A Kiemeney; Leon F A G Massuger; Tanja Pejovic; Yukie Bean; Angela Brooks-Wilson; Linda E Kelemen; Linda S Cook; Nhu D Le; Bohdan Górski; Jacek Gronwald; Janusz Menkiszak; Claus K Høgdall; Lene Lundvall; Lotte Nedergaard; Svend Aage Engelholm; Ed Dicks; Jonathan Tyrer; Ian Campbell; Iain McNeish; James Paul; Nadeem Siddiqui; Rosalind Glasspool; Alice S Whittemore; Joseph H Rothstein; Valerie McGuire; Weiva Sieh; Hui Cai; Xiao-Ou Shu; Rachel T Teten; Rebecca Sutphen; John R McLaughlin; Steven A Narod; Catherine M Phelan; Alvaro N Monteiro; David Fenstermacher; Hui-Yi Lin; Jennifer B Permuth; Thomas A Sellers; Y Ann Chen; Ya-Yu Tsai; Zhihua Chen; Aleksandra Gentry-Maharaj; Simon A Gayther; Susan J Ramus; Usha Menon; Anna H Wu; Celeste L Pearce; David Van Den Berg; Malcolm C Pike; Agnieszka Dansonka-Mieszkowska; Joanna Plisiecka-Halasa; Joanna Moes-Sosnowska; Jolanta Kupryjanczyk; Paul Dp Pharoah; Honglin Song; Ingrid Winship; Georgia Chenevix-Trench; Graham G Giles; Sean V Tavtigian; Doug F Easton; Roger L Milne Journal: J Med Genet Date: 2016-09-05 Impact factor: 6.318
Authors: Chunling Hu; Steven N Hart; Rohan Gnanaolivu; Hongyan Huang; Kun Y Lee; Jie Na; Chi Gao; Jenna Lilyquist; Siddhartha Yadav; Nicholas J Boddicker; Raed Samara; Josh Klebba; Christine B Ambrosone; Hoda Anton-Culver; Paul Auer; Elisa V Bandera; Leslie Bernstein; Kimberly A Bertrand; Elizabeth S Burnside; Brian D Carter; Heather Eliassen; Susan M Gapstur; Mia Gaudet; Christopher Haiman; James M Hodge; David J Hunter; Eric J Jacobs; Esther M John; Charles Kooperberg; Allison W Kurian; Loic Le Marchand; Sara Lindstroem; Tricia Lindstrom; Huiyan Ma; Susan Neuhausen; Polly A Newcomb; Katie M O'Brien; Janet E Olson; Irene M Ong; Tuya Pal; Julie R Palmer; Alpa V Patel; Sonya Reid; Lynn Rosenberg; Dale P Sandler; Christopher Scott; Rulla Tamimi; Jack A Taylor; Amy Trentham-Dietz; Celine M Vachon; Clarice Weinberg; Song Yao; Argyrios Ziogas; Jeffrey N Weitzel; David E Goldgar; Susan M Domchek; Katherine L Nathanson; Peter Kraft; Eric C Polley; Fergus J Couch Journal: N Engl J Med Date: 2021-01-20 Impact factor: 91.245
Authors: Bryson W Katona; Jessica M Long; Nuzhat A Ahmad; Sara Attalla; Angela R Bradbury; Erica L Carpenter; Dana F Clark; Gillain Constantino; Koushik K Das; Susan M Domchek; Christina Dudzik; Jessica Ebrahimzadeh; Gregory G Ginsberg; Jordan Heiman; Michael L Kochman; Kara N Maxwell; Danielle B McKenna; Jacquelyn Powers; Payal D Shah; Kirk J Wangensteen; Anil K Rustgi Journal: Cancer Prev Res (Phila) Date: 2021-08-02
Authors: Rachel A Pozzar; Fangxin Hong; Niya Xiong; Jill E Stopfer; Manan M Nayak; Meghan Underhill-Blazey Journal: Fam Cancer Date: 2021-03-10 Impact factor: 2.375
Authors: Dominika Wokołorczyk; Wojciech Kluźniak; Klaudia Stempa; Bogna Rusak; Tomasz Huzarski; Jacek Gronwald; Katarzyna Gliniewicz; Aniruddh Kashyap; Sylwia Morawska; Tadeusz Dębniak; Anna Jakubowska; Marek Szwiec; Paweł Domagała; Jan Lubiński; Steven A Narod; Mohammad R Akbari; Cezary Cybulski Journal: Br J Cancer Date: 2021-05-18 Impact factor: 7.640
Authors: Marleah Dean; Ann L Tezak; Sabrina Johnson; Joy K Pierce; Anne Weidner; Kate Clouse; Tuya Pal; Deborah Cragun Journal: Patient Educ Couns Date: 2021-01-05
Authors: Burcu F Darst; Tokhir Dadaev; Ed Saunders; Xin Sheng; Peggy Wan; Loreall Pooler; Lucy Y Xia; Stephen Chanock; Sonja I Berndt; Susan M Gapstur; Victoria Stevens; Demetrius Albanes; Stephanie J Weinstein; Vincent Gnanapragasam; Graham G Giles; Tu Nguyen-Dumont; Roger L Milne; Mark Pomerantz; Julie A Schmidt; Lorelei Mucci; William J Catalona; Kurt N Hetrick; Kimberly F Doheny; Robert J MacInnis; Melissa C Southey; Rosalind A Eeles; Fredrik Wiklund; Zsofia Kote-Jarai; David V Conti; Christopher A Haiman Journal: J Natl Cancer Inst Date: 2021-05-04 Impact factor: 13.506