| Literature DB >> 3184120 |
H Shinkai1, K Toi, I Kumashiro, Y Seto, M Fukuma, K Dan, S Toyoshima.
Abstract
N-Benzoyl-DL-phenylalanine (1) was found to possess hypoglycemic activity. A series of the analogues of compound 1 were prepared and evaluated for their blood glucose lowering activity. Both the steric effects of the phenylalanine moiety and the effects of variations in the acyl moiety were investigated. This study elucidated some of the structure-activity relationships and led to the development of N-(4-ethylbenzoyl)-D-phenylalanine (34), which was 50 times more potent than the initial compound 1.Entities:
Mesh：
Substances：
Year: 1988 PMID： 3184120 DOI： 10.1021/jm00119a007
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446