Niv Ben-Shabat1, Shmuel Tiosano1, Ora Shovman1, Doron Comaneshter1, Yehuda Shoenfeld1, Arnon D Cohen1, Howard Amita1. 1. From the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; Department of Medicine B, Sheba Medical Center, Tel Hashomer; The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer; Chief Physician's Office, Clalit Health Services, Tel Aviv; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel; Laboratory of the Mosaics of Autoimmunity, Saint Petersburg University, Saint Petersburg, Russia. N. Ben-Shabat, BMSc, Sackler Faculty of Medicine, Tel Aviv University; S. Tiosano, MD, MPH, Department of Medicine B, Sheba Medical Center, and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center; O. Shovman, MD, Sackler Faculty of Medicine, Tel Aviv University, and Department of Medicine B, Sheba Medical Center, and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center; D. Comaneshter, PhD, Chief Physician's Office, Clalit Health Services; Y. Shoenfeld, MD, FRCP, Sackler Faculty of Medicine, Tel Aviv University, and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, and Chief Physician's Office, Clalit Health Services, and Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, and Laboratory of the Mosaics of Autoimmunity, Saint Petersburg University; A.D. Cohen, MD, PhD, Chief Physician's Office, Clalit Health Services, and Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev; H. Amital, MD, MHA, Sackler Faculty of Medicine, Tel Aviv University, and Department of Medicine B, Sheba Medical Center, and The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center. A.D. Cohen and H. Amital contributed equally to this work. Address correspondence to Dr. H. Amital, Head, Department of Medicine B, Sheba Medical Center, Tel-Hashomer, 52621, Israel. E-mail: howard.amital@sheba.health.gov.il. Accepted for publication December 6, 2019.
Abstract
OBJECTIVE: Studies regarding mortality among patients with giant cell arteritis (GCA) have yielded conflicting results. Thus in this large population-based study we aimed to examine whether GCA is associated with increased mortality, and if so, the effect of age at diagnosis and sex on the association. METHODS: We used the medical database of Clalit Health Services for this retrospective cohort study. Followup was from January 1, 2002, and continued until death or end of followup on September 1, 2018. Incident GCA patients were compared with age- and sex-matched controls. Estimated median survival times were calculated using the Kaplan-Meier method. HR for all-cause mortality were obtained by the Cox proportional hazard model, adjusted for sociodemographic variables and cardiovascular risk factors. RESULTS: The study included 7294 patients with GCA and 33,688 controls. The mean age at start of followup was 72.1 ± 9.9 years with 69.2% females. Estimated median survival time was 13.1 years (95% CI 12.6-13.5) in patients with GCA compared with 14.4 years (95% CI 14.1-14.6) in controls (p < 0.001). The multivariate analysis demonstrated increased mortality risk in the first 2 years after diagnosis (HR 1.14, 95% CI 1.04-1.25) and > 10 years after diagnosis (HR 1.14, 95% CI 1.02-1.3). The mortality risk was higher in patients diagnosed at ≤ 70 years of age [HR 1.5 (95% CI 1.14-1.99) 0-2 yrs; HR 1.38 (95% CI 1.1-1.7) > 10 yrs]. CONCLUSION: Patients with GCA have a minor decrease in longterm survival compared to age- and sex-matched controls. The seen difference is due to excess mortality in the first 2 years, and > 10 years after diagnosis. Patients diagnosed ≤ 70 years of age are at greater risk.
OBJECTIVE: Studies regarding mortality among patients with giant cell arteritis (GCA) have yielded conflicting results. Thus in this large population-based study we aimed to examine whether GCA is associated with increased mortality, and if so, the effect of age at diagnosis and sex on the association. METHODS: We used the medical database of Clalit Health Services for this retrospective cohort study. Followup was from January 1, 2002, and continued until death or end of followup on September 1, 2018. Incident GCApatients were compared with age- and sex-matched controls. Estimated median survival times were calculated using the Kaplan-Meier method. HR for all-cause mortality were obtained by the Cox proportional hazard model, adjusted for sociodemographic variables and cardiovascular risk factors. RESULTS: The study included 7294 patients with GCA and 33,688 controls. The mean age at start of followup was 72.1 ± 9.9 years with 69.2% females. Estimated median survival time was 13.1 years (95% CI 12.6-13.5) in patients with GCA compared with 14.4 years (95% CI 14.1-14.6) in controls (p < 0.001). The multivariate analysis demonstrated increased mortality risk in the first 2 years after diagnosis (HR 1.14, 95% CI 1.04-1.25) and > 10 years after diagnosis (HR 1.14, 95% CI 1.02-1.3). The mortality risk was higher in patients diagnosed at ≤ 70 years of age [HR 1.5 (95% CI 1.14-1.99) 0-2 yrs; HR 1.38 (95% CI 1.1-1.7) > 10 yrs]. CONCLUSION:Patients with GCA have a minor decrease in longterm survival compared to age- and sex-matched controls. The seen difference is due to excess mortality in the first 2 years, and > 10 years after diagnosis. Patients diagnosed ≤ 70 years of age are at greater risk.
Authors: Dan Pugh; Maira Karabayas; Neil Basu; Maria C Cid; Ruchika Goel; Carl S Goodyear; Peter C Grayson; Stephen P McAdoo; Justin C Mason; Catherine Owen; Cornelia M Weyand; Taryn Youngstein; Neeraj Dhaun Journal: Nat Rev Dis Primers Date: 2022-01-06 Impact factor: 65.038