Jakrin Kewcharoen1, Sittinun Thangjui2, Chanavuth Kanitsoraphan1, Chol Techorueangwiwat1, Poemlarp Mekraksakit3, Wasawat Vutthikraivit3,4. 1. University of Hawaii Internal Medicine Residency Program, Honolulu, HI, USA. 2. Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand. 3. Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA. 4. Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Abstract
BACKGROUND: Traditional risk factors for worse outcome in heart failure (HF) are well-established. However, there are still many unknown risk factors for worse outcome in this population. Several studies have shown that unmarried status is associated with an increased risk of rehospitalization and mortality in HF patients. However, there is no systematic review or meta-analysis to confirm this association. We performed a systematic review and meta-analysis to explore the effect of marital status on outcome regarding mortality and rehospitalization in HF population. METHODS: We searched the databases of MEDLINE and EMBASE from inception to July 2019. Included studies were published cohort studies or randomised controlled trials reporting rates of mortality and/or rehospitalization in HF patients, married and unmarried. Data from each study were combined using the random-effects model. RESULTS: Ten studies were included in our meta-analysis. We found that unmarried status is associated with increased risk of mortality (pooled OR = 1.52, 95%CI = 1.30-1.78, p < .001), increased risk of rehospitalization (pooled OR = 1.80, 95%CI = 1.18-2.74, p = .007), and increased risk of combined endpoint of mortality and rehospitalization (pooled OR = 1.72, 95%CI = 1.36-2.17, p < .001). CONCLUSIONS: Our meta-analysis demonstrated that being unmarried, divorced, and widowed is associated with a worse outcome in HF population regarding mortality and rehospitalization rate.
BACKGROUND: Traditional risk factors for worse outcome in heart failure (HF) are well-established. However, there are still many unknown risk factors for worse outcome in this population. Several studies have shown that unmarried status is associated with an increased risk of rehospitalization and mortality in HF patients. However, there is no systematic review or meta-analysis to confirm this association. We performed a systematic review and meta-analysis to explore the effect of marital status on outcome regarding mortality and rehospitalization in HF population. METHODS: We searched the databases of MEDLINE and EMBASE from inception to July 2019. Included studies were published cohort studies or randomised controlled trials reporting rates of mortality and/or rehospitalization in HF patients, married and unmarried. Data from each study were combined using the random-effects model. RESULTS: Ten studies were included in our meta-analysis. We found that unmarried status is associated with increased risk of mortality (pooled OR = 1.52, 95%CI = 1.30-1.78, p < .001), increased risk of rehospitalization (pooled OR = 1.80, 95%CI = 1.18-2.74, p = .007), and increased risk of combined endpoint of mortality and rehospitalization (pooled OR = 1.72, 95%CI = 1.36-2.17, p < .001). CONCLUSIONS: Our meta-analysis demonstrated that being unmarried, divorced, and widowed is associated with a worse outcome in HF population regarding mortality and rehospitalization rate.
Entities:
Keywords:
Marital status; heart failure; mortality; rehospitalization; single
Authors: Bihter Senturk; Hakki Kaya; Ahmet Celik; Lutfu Bekar; Hasan Gungor; Mehdi Zoghi; Dilek Ural; Yuksel Cavusoglu; Ahmet Temizhan; Mehmet Birhan Yilmaz Journal: North Clin Istanb Date: 2021-01-29