Jonathan M Payne1,2, Kristina M Haebich1, Rachel MacKenzie3, Karin S Walsh4, Stephen J C Hearps1, David Coghill1,2, Belinda Barton5,6, Natalie A Pride5,6, Nicole J Ullrich7, James H Tonsgard8, David Viskochil9, Elizabeth K Schorry10, Laura Klesse11, Michael J Fisher12, David H Gutmann13, Tena Rosser14, Roger J Packer4, Bruce Korf15, Maria T Acosta4, Mark A Bellgrove16, Kathryn N North1,2. 1. Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia. 2. University of Melbourne, Parkville, Victoria, Australia. 3. La Trobe University, Bundoora, Victoria, Australia. 4. Children's National Health System, Washington, DC, USA. 5. The Children's Hospital at Westmead, New South Wales, Australia. 6. The University of Sydney, New South Wales, Australia. 7. Boston Children's Hospital, MA, USA. 8. The University of Chicago Medicine Comer Children's Hospital, IL, USA. 9. The University of Utah, Salt Lake City, USA. 10. Cincinnati Children's Hospital Medical Center, OH, USA. 11. University of Texas Southwestern Medical Center, Dallas, USA. 12. Children's Hospital of Philadelphia, PA, USA. 13. Washington University School of Medicine, St Louis, MO, USA. 14. Children's Hospital Los Angeles, CA, USA. 15. The University of Alabama at Birmingham, USA. 16. Monash University, Clayton, Victoria, Australia.
Abstract
Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1.
Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1.
Entities:
Keywords:
ADHD; cognition; executive function; functional impairment; neurofibromatosis type 1
Authors: Eve Lalancette; Audrey-Rose Charlebois-Poirier; Kristian Agbogba; Inga Sophia Knoth; Emily J H Jones; Luke Mason; Sébastien Perreault; Sarah Lippé Journal: J Neurodev Disord Date: 2022-07-22 Impact factor: 4.074
Authors: Gary Rance; Julien Zanin; Alice Maier; Donella Chisari; Kristina M Haebich; Kathryn N North; Gabriel Dabscheck; Marc L Seal; Martin B Delatycki; Jonathan M Payne Journal: JAMA Netw Open Date: 2021-12-01