| Literature DB >> 31838715 |
Paul J Davis1,2,3, Shaker A Mousa4, Geraldine P Schechter5,6, Hung-Yun Lin7,8,9,10.
Abstract
Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.Entities:
Keywords: 3,5,3′-Triiodo-L-thyronine (T3); Degranulation; Integrin; L-Thyroxine (T4); Metastasis; Thyroid hormone receptors; Tumor cell invasiveness
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Year: 2019 PMID： 31838715 DOI： 10.1007/s12672-019-00371-4
Source DB: PubMed Journal: Horm Cancer ISSN： 1868-8497 Impact factor: 3.869