| Literature DB >> 31838455 |
Cong Wang1, Honghui Cao2, Shen Gu2, Chaowen Shi2, Xiang Chen2, Xiaodong Han3.
Abstract
Idiopathic pulmonary fibrosis (IPF) is a serious lung disease that involved the myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSCs). However, the specific molecular mechanisms of myofibroblast differentiation of LR-MSCs still remain a mystery. In this study, a comprehensive analysis of miRNAs and mRNAs changes in LR-MSCs treated with TGF-β1 was performed. Through computational approaches, the pivotal roles of differentially expressed miRNAs that were associated with tight junction, pathways in cancer, focal adhesion, and cytokine-cytokine receptor interaction were shown. Kruppel-like factor 4 (Klf4) and inhibitor of growth family, member 5 (Ing5) may be the targets for the therapy of pulmonary fibrosis by inhibiting myofibroblast differentiation of LR-MSCs and EMT. Collectively, a molecular paradigm for understanding myofibroblast differentiation of LR-MSCs in IPF was provided by the integrated miRNA/mRNA analyses.Entities:
Keywords: Idiopathic pulmonary fibrosis; Kruppel-like factor 4; Lung resident mesenchymal stem cells; Myofibroblast differentiation; miRNA/mRNA integrated analysis
Mesh：
Substances：
Year: 2019 PMID： 31838455 DOI： 10.1016/j.diff.2019.11.002
Source DB: PubMed Journal: Differentiation ISSN： 0301-4681 Impact factor: 3.880