Literature DB >> 31837982

CPSF7 regulates liver cancer growth and metastasis by facilitating WWP2-FL and targeting the WWP2/PTEN/AKT signaling pathway.

Shiji Fang1, Dengke Zhang1, Wei Weng1, Xiuling Lv1, Liyun Zheng2, Minjiang Chen1, Xiaoxi Fan1, Jianting Mao1, Chenchen Mao1, Yani Ye1, Min Xu3, Jiansong Ji4.   

Abstract

Alternative splicing within a gene can create different versions of an mRNA, called isoforms. CFIm, composed of a small subunit CFIm25 and two large subunits CFIm68 and CFIm59 (also known as CPSF7), has been proposed as an enhancer-dependent activator of mRNA 3' processing. In this study, we investigated the role of CPSF7 in hepatocellular carcinoma. Experimental evidence suggests that the expression level of CPSF7 is higher in liver cancer cells and tissues than in non-tumor hepatic cells and tissues. Furthermore, knockdown of CPSF7 effectively suppressed cell proliferation, migration and colony formation in liver cancer cells by inhibiting PTEN/AKT signaling. CPSF7 promoted WWP2-FL due to the presence of PTEN ubiquitination sites in this longer transcript. Taken together, we identified that CPSF7 regulates liver cancer growth by targeting WWP2-FL that in turn regulates AKT activation in a PTEN-dependent manner.
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Alternative polyadenylation; CPSF7; Hepatocellular carcinoma; PTEN/AKT signaling; WWP2

Mesh：

Substances：

Year:  2019        PMID： 31837982     DOI： 10.1016/j.bbamcr.2019.118624

Source DB:  PubMed          Journal:  Biochim Biophys Acta Mol Cell Res        ISSN： 0167-4889            Impact factor:   4.739


  7 in total

1.  The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia.

Authors:  Xinxin Lu; Xinyue Huang; Haiqi Xu; Saien Lu; Shilong You; Jiaqi Xu; Qianru Zhan; Chao Dong; Ning Zhang; Ying Zhang; Liu Cao; Xingang Zhang; Naijin Zhang; Lijun Zhang
Journal:  Cell Death Discov       Date:  2022-10-18

2.  The HECT family of E3 ubiquitin ligases and PTEN.

Authors:  Min Sup Song; Pier Paolo Pandolfi
Journal:  Semin Cancer Biol       Date:  2021-06-12       Impact factor: 15.707

Review 3.  Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers.

Authors:  Asal Jalal Abadi; Ali Zarrabi; Mohammad Hossein Gholami; Sepideh Mirzaei; Farid Hashemi; Amirhossein Zabolian; Maliheh Entezari; Kiavash Hushmandi; Milad Ashrafizadeh; Haroon Khan; Alan Prem Kumar
Journal:  Biomolecules       Date:  2021-02-18

4.  Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade.

Authors:  Hsin-Wei Tseng; Anthony Mota-Sydor; Rania Leventis; Predrag Jovanovic; Ivan Topisirovic; Thomas F Duchaine
Journal:  Nucleic Acids Res       Date:  2022-08-22       Impact factor: 19.160

Review 5.  The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response.

Authors:  Xinxin Lu; Haiqi Xu; Jiaqi Xu; Saien Lu; Shilong You; Xinyue Huang; Naijin Zhang; Lijun Zhang
Journal:  Front Physiol       Date:  2022-08-26       Impact factor: 4.755

6.  Association of Common Genetic Variants in the CPSF7 and SDHAF2 Genes with Canine Idiopathic Pulmonary Fibrosis in the West Highland White Terrier.

Authors:  Ignazio S Piras; Christiane Bleul; Ashley Siniard; Amanda J Wolfe; Matthew D De Both; Alvaro G Hernandez; Matthew J Huentelman
Journal:  Genes (Basel)       Date:  2020-05-30       Impact factor: 4.096

7.  NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway.

Authors:  Xinxin Zhang; Hui Wang; Yajuan Han; Mengqi Zhu; Zaozhi Song; Dankai Zhan; Jianguang Jia
Journal:  Onco Targets Ther       Date:  2020-11-04       Impact factor: 4.147
  7 in total

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