Jae Ri Kim1, Kee-Taek Jang2, Jin-Young Jang3, Kyungbun Lee4, Jung Hoon Kim5, Haeryoung Kim6, Sun-Whe Kim1, Wooil Kwon1, Dong Wook Choi7, JinSeok Heo7, In Woong Han7, Shin Hwang8, Wan-Joon Kim8, Seung-Mo Hong9, Dong-Sik Kim10, Young-Dong Yu10, Joo Young Kim11, Yang Won Nah12, Hyung Woo Park12, Hye-Jeong Choi13, Ho-Seong Han14, Yoo-Seok Yoon14, Sang Jae Park15, Eun Kyung Hong16, Hyung Il Seo17, Do Youn Park18, Koo Jeong Kang19, Yu Na Kang20, Hee Chul Yu21, Woo Sung Moon22, Chang-Sup Lim23, Jeong Mo Bae24, Sungho Jo25, Wonae Lee26, Young Hun Roh27, Jin Sook Jeong28, Chi-Young Jeong29, Jong Sil Lee30, In-Sang Song31, Kyung-Hee Kim32, Ho Gak Kim33, Chang Ho Cho34, Sun-Hyung Joo35, Kyu Yeoun Won36, Hong Jin Kim37, Joon Hyuk Choi38, Chong-Woo Chu39, Jung Hee Lee40, Il Young Park41, Heejeong Lee42, Seung Eun Lee43, Hee Sung Kim44, Hyeon Kook Lee45, Min-Sun Cho46, Hongbeom Kim47, Kang Min Han48. 1. Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea. 2. Dept. of Pathology, Sungkyunkwan University School of Medicine (Samsung Medical Center), South Korea. 3. Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea. Electronic address: jangjy4@gmail.com. 4. Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea. 5. Dept. of Radiology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea. 6. Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Hospital), South Korea; Dept. of Pathology, Seoul National University College of Medicine (Seoul National University Bundang Hospital), South Korea. 7. Dept. of Surgery, Sungkyunkwan University School of Medicine (Samsung Medical Center), South Korea. 8. Dept. of Surgery, University of Ulsan College of Medicine (Asan Medical Center), South Korea. 9. Dept. of Pathology, University of Ulsan College of Medicine (Asan Medical Center), South Korea. 10. Dept. of Surgery, Korea University College of Medicine, South Korea. 11. Dept. of Pathology, Korea University College of Medicine, South Korea. 12. Dept. of Surgery, University of Ulsan College of Medicine (Ulsan University Hospital), South Korea. 13. Dept. of Pathology, University of Ulsan College of Medicine (Ulsan University Hospital), South Korea. 14. Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Bundang Hospital), South Korea. 15. Dept. of Surgery, National Cancer Center, South Korea. 16. Dept. of Pathology, National Cancer Center, South Korea. 17. Dept. of Surgery, Pusan National University School of Medicine (Pusan National University Hospital), South Korea. 18. Dept. of Pathology, Pusan National University School of Medicine (Pusan National University Hospital), South Korea. 19. Dept. of Surgery, Keimyung University School of Medicine, South Korea. 20. Dept. of Pathology, Keimyung University School of Medicine, South Korea. 21. Dept. of Surgery, Chonbuk National University Medical School, South Korea. 22. Dept. of Pathology, Chonbuk National University Medical School, South Korea. 23. Dept. of Surgery, Seoul National University College of Medicine (Boramae Medical Center), South Korea. 24. Dept. of Pathology, Seoul National University College of Medicine (Boramae Medical Center), South Korea. 25. Dept. of Surgery, Dankook University College of Medicine, South Korea. 26. Dept. of Pathology, Dankook University College of Medicine, South Korea. 27. Dept. of Surgery, Dong-A University College of Medicine, South Korea. 28. Dept. of Pathology, Dong-A University College of Medicine, South Korea. 29. Dept. of Surgery, Gyeongsang National University Postgraduate School of Medicine, South Korea. 30. Dept. of Pathology, Gyeongsang National University Postgraduate School of Medicine, South Korea. 31. Dept. of Surgery, Chungnam National University School of Medicine, South Korea. 32. Dept. of Pathology, Chungnam National University School of Medicine, South Korea. 33. Dept. of Surgery, Daegu Catholic University School of Medicine, South Korea. 34. Dept. of Pathology, Daegu Catholic University School of Medicine, South Korea. 35. Dept. of Surgery, Kyung Hee University School of Medicine, South Korea. 36. Dept. of Pathology, Kyung Hee University School of Medicine, South Korea. 37. Dept. of Surgery, Yeungnam University College of Medicine, South Korea. 38. Dept. of Pathology, Yeungnam University College of Medicine, South Korea. 39. Dept. of Surgery, Pusan National University School of Medicine (Pusan National University Yangsan Hospital), South Korea. 40. Dept. of Pathology, Pusan National University School of Medicine (Pusan National University Yangsan Hospital), South Korea. 41. Dept. of Surgery, Catholic University College of Medicine, South Korea. 42. Dept. of Pathology, Catholic University College of Medicine, South Korea. 43. Dept. of Surgery, Chung-Ang University College of Medicine, South Korea. 44. Dept. of Pathology, Chung-Ang University College of Medicine, South Korea. 45. Dept. of Surgery, Ewha Womans University School of Medicine, South Korea. 46. Dept. of Pathology, Ewha Womans University School of Medicine, South Korea. 47. Dept. of Surgery, Seoul National University College of Medicine (Seoul National University Hospital), South Korea; Dept. of Surgery, Dongguk University College of Medicine (Dongguk University Ilsan Hospital), South Korea. 48. Dept. of Pathology, Dongguk University College of Medicine (Dongguk University Ilsan Hospital), South Korea.
Abstract
BACKGROUND: IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. METHODS: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. RESULTS: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the "Jang & Kim's modified anatomical classification," 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010-4.433]). CONCLUSIONS: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.
BACKGROUND:IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. METHODS: Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. RESULTS: Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the "Jang & Kim's modified anatomical classification," 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010-4.433]). CONCLUSIONS: This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type.
Authors: Matthew H Lee; Venkata S Katabathina; Meghan G Lubner; Hardik U Shah; Srinivasa R Prasad; Kristina A Matkowskyj; Perry J Pickhardt Journal: Radiographics Date: 2021-10 Impact factor: 6.312
Authors: Evangelos G Baltagiannis; Christina Kalyvioti; Anastasia Glantzouni; Anna Batistatou; Petros Tzimas; Georgios K Glantzounis Journal: Ann Med Surg (Lond) Date: 2021-02-12