Literature DB >> 31836921

Can we be sure that the human Plasmodium exoerythrocytic developmental stages occur exclusively in the liver?

Gabriele Franken1, Joachim Richter2, Alfons Labisch3.   

Abstract

The development cycle of the malaria parasite, Plasmodium sp., in humans takes place after an infected female Anopheles mosquito injects motile infective forms called sporozoites into the bloodstream. Sporozoites migrate via blood vessels to the liver. This pre-erythrocytic tissue stage is widely accepted to occur in humans exclusively in the liver, contrary to avian malaria where this may occur also in other parenchymatous organs. This concept is based on research conducted by English researchers Henry Shortt and P.C.C. Garnham in the late 1940s. Although Italian researchers as, e.g., Giulio Raffaele, additionally claimed the presence of the parasites in the bone marrow, this is not well acknowledged. So, the question remains whether there exists also a tissue life cycle stage in humans.

Entities:  

Keywords:  Giulio Raffaele; Henry Shortt; History of malaria research; Lilly Mudrow; P. C. C. Garnham; Plasmodium; Theory of malaria research; Tissue stage; Walter Kikuth

Mesh:

Year:  2019        PMID: 31836921     DOI: 10.1007/s00436-019-06564-8

Source DB:  PubMed          Journal:  Parasitol Res        ISSN: 0932-0113            Impact factor:   2.289


  17 in total

1.  [On the problem of blood infection with plasmodia and method of microscopic demonstration of pigment].

Authors:  A WESTPHAL
Journal:  Z Tropenmed Parasitol       Date:  1962-12

2.  Henry Edward Shortt: 15 April 1887-9 November 1987.

Authors:  P C Garnham
Journal:  Biogr Mem Fellows R Soc       Date:  1988

3.  Source of homologous parasites in recurrent Plasmodium vivax malaria.

Authors:  Miles B Markus
Journal:  J Infect Dis       Date:  2012-06-13       Impact factor: 5.226

4.  Exo-erythrocytic schizogony in malaria.

Authors:  P C C GARNHAM
Journal:  Trop Dis Bull       Date:  1948-10

5.  Pre-erythrocytic stage in mammalian malaria parasites.

Authors:  H E SHORTT; P C C GARNHAM
Journal:  Nature       Date:  1948-01-24       Impact factor: 49.962

6.  The exoerythrocytic parasites of Plasmodium cynomolgi.

Authors:  H E SHORTT; P C C GARNHAM
Journal:  Trans R Soc Trop Med Hyg       Date:  1948-05       Impact factor: 2.184

7.  The pre-erythrocytic development of Plasmodium cynomolgi and Plasmodium vivax.

Authors:  H E SHORTT; P C C GARNHAM
Journal:  Trans R Soc Trop Med Hyg       Date:  1948-05       Impact factor: 2.184

8.  The pre-erythrocytic stage of mammalian malaria.

Authors:  H E SHORTT; P C C GARNHAM; B MALAMOS
Journal:  Br Med J       Date:  1948-01-31

9.  The pre-erythrocytic stage of Plasmodium falciparum; a preliminary note.

Authors:  H E SHORTT; N H FAIRLEY
Journal:  Br Med J       Date:  1949-11-05

10.  Do hypnozoites cause relapse in malaria?

Authors:  Miles B Markus
Journal:  Trends Parasitol       Date:  2015-03-26
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  1 in total

Review 1.  An Ecologically Framed Comparison of The Potential for Zoonotic Transmission of Non-Human and Human-Infecting Species of Malaria Parasite.

Authors:  Nicole F Clark; Andrew W Taylor-Robinson
Journal:  Yale J Biol Med       Date:  2021-06-30
  1 in total

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