Literature DB >> 3183686

Oral use of human alpha interferon in cats.

J M Cummins1, M B Tompkins, R G Olsen, W A Tompkins, M G Lewis.   

Abstract

Low doses (0.5 or 5.0 U) of human alpha interferon (HuIFN alpha) given orally prevented the experimental development of fatal feline leukemia virus (FeLV)-related disease. Twenty-one FeLV-susceptible cats were inoculated with the Rickard strain of FeLV. Cats given oral HuIFN alpha survived significantly (p less than 0.001) longer than untreated FeLV-infected cats. Moreover, only 4 of 13 (30.8%) HuIFN alpha-treated cats developed clinical disease during the course of the study, whereas 100% of the untreated control cats developed fatal FeLV-related disease. Thus, in experimental retroviral disease, heterologous species HuIFN alpha provided significant clinical benefits.

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Year:  1988        PMID： 3183686

Source DB:  PubMed          Journal:  J Biol Response Mod        ISSN： 0732-6580


  11 in total

1.  Effects of interferon alpha (INF-alpha) therapy on peripheral blood lymphocyte subsets from FIV and FeLV naturally infected cats.

Authors:  F Riondato; P Gianella; R Guglielmino; A Cagnasso; S Bo
Journal:  Vet Res Commun       Date:  2003-09       Impact factor: 2.459

Review 2.  Absorption of cytokines via oropharyngeal-associated lymphoid tissues. Does an unorthodox route improve the therapeutic index of interferon?

Authors:  V Bocci
Journal:  Clin Pharmacokinet       Date:  1991-12       Impact factor: 6.447

3.  Alpha interferon (2b) in combination with zidovudine for the treatment of presymptomatic feline leukemia virus-induced immunodeficiency syndrome.

Authors:  N S Zeidner; M H Myles; C K Mathiason-DuBard; M J Dreitz; J I Mullins; E A Hoover
Journal:  Antimicrob Agents Chemother       Date:  1990-09       Impact factor: 5.191

4.  Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses.

Authors:  M Marinaro; P N Boyaka; F D Finkelman; H Kiyono; R J Jackson; E Jirillo; J R McGhee
Journal:  J Exp Med       Date:  1997-02-03       Impact factor: 14.307

5.  Transgenic tomato expressing interleukin-12 has a therapeutic effect in a murine model of progressive pulmonary tuberculosis.

Authors:  A L Elías-López; B Marquina; A Gutiérrez-Ortega; D Aguilar; M Gomez-Lim; R Hernández-Pando
Journal:  Clin Exp Immunol       Date:  2008-08-22       Impact factor: 4.330

6.  Follow-Up of Viral Parameters in FeLV- or FIV-Naturally Infected Cats Treated Orally with Low Doses of Human Interferon Alpha.

Authors:  Esperanza Gomez-Lucia; Victorio M Collado; Guadalupe Miró; Sonsoles Martín; Laura Benítez; Ana Doménech
Journal:  Viruses       Date:  2019-09-11       Impact factor: 5.048

7.  Effect of recombinant human interferon-alpha in vitro and in vivo on mitogen-induced lymphocyte blastogenesis in cats.

Authors:  R C Weiss; T Oostrom-Ram
Journal:  Vet Immunol Immunopathol       Date:  1990-02       Impact factor: 2.046

8.  Use of recombinant interferon omega in feline retrovirosis: from theory to practice.

Authors:  Ana Doménech; Guadalupe Miró; Victorio M Collado; Natalia Ballesteros; Leticia Sanjosé; Elena Escolar; Sonsoles Martin; Esperanza Gomez-Lucia
Journal:  Vet Immunol Immunopathol       Date:  2011-06-12       Impact factor: 2.046

Review 9.  Therapeutic and Prophylactic Use of Oral, Low-Dose IFNs in Species of Veterinary Interest: Back to the Future.

Authors:  Sara Frazzini; Federica Riva; Massimo Amadori
Journal:  Vet Sci       Date:  2021-06-11

10.  Low-dose oral interferon modulates expression of inflammatory and autoimmune genes in cattle.

Authors:  Stephen W Mamber; Jeremy Lins; Volkan Gurel; David P Hutcheson; Pablo Pinedo; David Bechtol; Steven Krakowka; Rachel Fields-Henderson; Joseph M Cummins
Journal:  Vet Immunol Immunopathol       Date:  2016-03-04       Impact factor: 2.046
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