Zhuxuan Fu1, Kirsten Moysich2, Roberta B Ness3, Francesmary Modugno4. 1. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. Electronic address: Zhuxuan.Fu@pitt.edu. 2. Roswell Park Cancer Institute, Buffalo, NY, USA. Electronic address: Moysich@roswellpark.org. 3. University of Texas School of Public Health, Houston, TX, USA. Electronic address: Roberta.B.Ness@uth.tmc.edu. 4. Womens Cancer Research Program, Magee-Womens Research Institute and UPMC Hillman Cancer Center, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: modugnof@upmc.edu.
Abstract
OBJECTIVE: To examine the association between gender of offspring and epithelial ovarian cancer (EOC). METHODS: We compared gender of offspring between 664 incident EOC cases and 1531 controls participating in a population-based study conducted in Pennsylvania, Ohio, and New York from 2003-2008. Multivariable unconditional logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) adjusting for potential confounders. RESULTS: Bearing a male offspring was associated with an 8 % lower EOC risk; bearing all boys was associated with an 11 % lower risk. Compared to bearing all girls, bearing all boys was associated with a 14 % decrease risk. Increasing number of male offspring increased the protective effect (adjusted-OR: 0.92, 0.91, 0.84, for 1, 2, and 3+ boys compared to all girls). Results where similar when limiting cases to invasive disease and to the high-grade serous histotype. CONCLUSION: Fetal sex, which influences maternal hormonal milieu, may impact EOC risk.
OBJECTIVE: To examine the association between gender of offspring and epithelial ovarian cancer (EOC). METHODS: We compared gender of offspring between 664 incident EOC cases and 1531 controls participating in a population-based study conducted in Pennsylvania, Ohio, and New York from 2003-2008. Multivariable unconditional logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) adjusting for potential confounders. RESULTS: Bearing a male offspring was associated with an 8 % lower EOC risk; bearing all boys was associated with an 11 % lower risk. Compared to bearing all girls, bearing all boys was associated with a 14 % decrease risk. Increasing number of male offspring increased the protective effect (adjusted-OR: 0.92, 0.91, 0.84, for 1, 2, and 3+ boys compared to all girls). Results where similar when limiting cases to invasive disease and to the high-grade serous histotype. CONCLUSION: Fetal sex, which influences maternal hormonal milieu, may impact EOC risk.
Authors: Wei-Hsuan Lo-Ciganic; Janice C Zgibor; Clareann H Bunker; Kirsten B Moysich; Robert P Edwards; Roberta B Ness Journal: Epidemiology Date: 2012-03 Impact factor: 4.822
Authors: Susan J Jordan; Adèle C Green; Christina M Nagle; Catherine M Olsen; David C Whiteman; Penelope M Webb Journal: Am J Epidemiol Date: 2009-07-28 Impact factor: 4.897
Authors: Francesmary Modugno; Zhuxuan Fu; Susan J Jordan; Aocs Group; Jenny Chang-Claude; Renée T Fortner; Marc T Goodman; Kirsten B Moysich; Joellen M Schildkraut; Andrew Berchuck; Elisa V Bandera; Bo Qin; Rebecca Sutphen; John R McLaughlin; Usha Menon; Susan J Ramus; Simon A Gayther; Aleksandra Gentry-Maharaj; Chloe Karpinskyj; Celeste L Pearce; Anna H Wu; Harvey A Risch; Penelope M Webb Journal: Eur J Epidemiol Date: 2020-09-21 Impact factor: 8.082