Anna Michela Gaeta1, Ivan D Benítez1,2, Carmen Jorge3, Gerard Torres1,2, Faride Dakterzada3, Olga Minguez1, Raquel Huerto3, Montse Pujol1, Anna Carnes3, Mireia Dalmases1,2, Aurora Gibert3, Ramón Farré4, Manuel Sanchez de la Torres1,2, Ferran Barbé1,2, Gerard Piñol-Ripoll5. 1. Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain. 2. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. 3. Unitat Trastorns Cognitius, Clinical Neuroscience Research, IRBLleida-Hospital Universitari Santa Maria Lleida, Lleida, Spain. 4. Unitat Biofísica I Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain. 5. Unitat Trastorns Cognitius, Clinical Neuroscience Research, IRBLleida-Hospital Universitari Santa Maria Lleida, Lleida, Spain. gerard_437302@hotmail.com.
Abstract
OBJECTIVE: To assess the prevalence of obstructive sleep apnea (OSA) in patients with mild-moderate Alzheimer's Disease (AD) and to evaluate cognitive characteristics according to the severity of OSA. METHODS: Patients with mild-moderate AD, recruited prospectively from a cognitive impairment unit, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index > 5/h. AD severity was assessed using the Mini-Mental State Examination and extensive neuropsychological battery. Epworth Sleepiness Scale and APOE status were analyzed. RESULTS: The cohort included 128 patients with a median [IQR] age of 75.0 [72.0;79.2] years and 57.8% were women. OSA was diagnosed in 116 subjects (90.6%). The distribution of mild, moderate and severe severity of OSA was 29 (22.7%), 37 (28.9%) and 50 (39.1%), respectively. Regarding sleep symptoms, the cohort showed normal values of daytime sleepiness (median EES score 5 [3, 8]), while nycturia (89.1%) and snoring (71.1%) were the most common symptoms. Participants with severe OSA included a higher proportion of older men, were associated with snoring and sedentariness. No significant differences in cognitive assessment were found between patients with and without severe OSA in any of the domains. The prevalence of APOE ε4 was not significantly different between patients with and without severe OSA. CONCLUSION: There was a high prevalence of OSA in patients with mild-moderate AD. OSA was not associated with sleepiness or worse cognitive function. APOE ε4 was not related to the presence or severity of OSA. Further longitudinal studies will be required to evaluate whether OSA impairs cognitive evolution in AD patients.
OBJECTIVE: To assess the prevalence of obstructive sleep apnea (OSA) in patients with mild-moderate Alzheimer's Disease (AD) and to evaluate cognitive characteristics according to the severity of OSA. METHODS:Patients with mild-moderate AD, recruited prospectively from a cognitive impairment unit, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index > 5/h. AD severity was assessed using the Mini-Mental State Examination and extensive neuropsychological battery. Epworth Sleepiness Scale and APOE status were analyzed. RESULTS: The cohort included 128 patients with a median [IQR] age of 75.0 [72.0;79.2] years and 57.8% were women. OSA was diagnosed in 116 subjects (90.6%). The distribution of mild, moderate and severe severity of OSA was 29 (22.7%), 37 (28.9%) and 50 (39.1%), respectively. Regarding sleep symptoms, the cohort showed normal values of daytime sleepiness (median EES score 5 [3, 8]), while nycturia (89.1%) and snoring (71.1%) were the most common symptoms. Participants with severe OSA included a higher proportion of older men, were associated with snoring and sedentariness. No significant differences in cognitive assessment were found between patients with and without severe OSA in any of the domains. The prevalence of APOE ε4 was not significantly different between patients with and without severe OSA. CONCLUSION: There was a high prevalence of OSA in patients with mild-moderate AD. OSA was not associated with sleepiness or worse cognitive function. APOE ε4 was not related to the presence or severity of OSA. Further longitudinal studies will be required to evaluate whether OSA impairs cognitive evolution in ADpatients.
Authors: Monica Moon Shieu; Afsara Zaheed; Carol Shannon; Ronald David Chervin; Alan Conceicao; Henry Lauris Paulson; Tiffany Joy Braley; Galit Levi Dunietz Journal: Neurology Date: 2022-05-06 Impact factor: 11.800
Authors: Chitra Lal; Indu Ayappa; Najib Ayas; Andrew E Beaudin; Camilla Hoyos; Clete A Kushida; Marta Kaminska; Anna Mullins; Sharon L Naismith; Ricardo S Osorio; Craig L Phillips; Ankit Parekh; Katie L Stone; Arlener D Turner; Andrew W Varga Journal: Ann Am Thorac Soc Date: 2022-08
Authors: Agata Gabryelska; Szymon Turkiewicz; Filip Franciszek Karuga; Marcin Sochal; Dominik Strzelecki; Piotr Białasiewicz Journal: Int J Mol Sci Date: 2022-01-10 Impact factor: 5.923