Yue Deng1, Brianna M Marsh1, Jackob Moskovitz1. 1. Mr. Deng, Ms. Marsh, and Dr. Moskovitz are with the Department of Pharmacology and Toxicology at the School of Pharmacy, University of Kansas in Lawrence, Kansas.
Abstract
Objective: Sporadic Alzheimer's disease (AD) is an oxidative, stress-dependent neurodegenerative disease. We investigated whether the levels of protein-methionine sulfoxide (MetO) in plasma could be a possible marker for AD in individuals with mild cognitive impariment (MCI). Design: We evaluated blood samples from patients with AD or MCI, as well as from normal controls, testing their MetO levels and superoxide dismutase (SOD) specific activity. Results: An increase of MetO levels of a particular protein of human plasma and a decrease of SOD activity were observed only in AD plasma. Conclusion: Monitoring the patterns of these plasma markers in patients with MCI could provide a warning sign for disease progression into AD.
Objective: Sporadic Alzheimer's disease (AD) is an oxidative, stress-dependent neurodegenerative disease. We investigated whether the levels of protein-methionine sulfoxide (MetO) in plasma could be a possible marker for AD in individuals with mild cognitive impariment (MCI). Design: We evaluated blood samples from patients with AD or MCI, as well as from normal controls, testing their MetO levels and superoxide dismutase (SOD) specific activity. Results: An increase of MetO levels of a particular protein of human plasma and a decrease of SOD activity were observed only in AD plasma. Conclusion: Monitoring the patterns of these plasma markers in patients with MCI could provide a warning sign for disease progression into AD.
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